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Resumo(s)
A Paragem Cárdio-Respiratória (PCR) de etiologia cardíaca, que ocorre fora do ambiente hospitalar, é uma das principais causas de morte em países desenvolvidos e mesmo após uma reanimação bem sucedida continua a ser responsável por uma elevada mortalidade e morbilidade. A rápida actuação perante a PCR vai determinar substancialmente o prognóstico do doente, no entanto é igualmente importante actuar após a reanimação cardíaca para evitar as lesões que ocorrem durante a Síndrome Pós-Paragem Cárdio-Respiratória (SPPCR). A hipotermia terapêutica (HT)/controlo da temperatura (CT) é uma das opções terapêuticas disponíveis que procura minimizar um dos mecanismos responsáveis pela SPPCR, a lesão cerebral pós-PCR. Em 2003 a HT foi pela primeira vez recomendada pela International Liaison Committe on Ressuscitation por ter demonstrado uma diminuição da mortalidade e por ser neuroprotectora. Contudo em 2013 novos estudos vieram colocar em causa a recomendação anteriormente proposta, sugerindo que não haverá benefício em diminuir a temperatura e que apenas se deverá controlar a temperatura com o propósito de evitar estados de hipertermia, que estão associados a um agravamento do prognóstico.
Out-of-hospital cardiac arrest is one of the leading causes of death in developed countries, and even after a successful resuscitation, it is still responsible for high mortality and morbidity. A fast act before cardiac arrest will be determinant for the prognosis of the patient, however it is important to treat the patient even after return of spontaneous circulation to avoid lesions that occur during the Post-Cardiac Arrest Syndrome. Therapeutic hypothermia/Target Temperature Management is one of the available therapeutic options that seeks to minimize one of the mechanisms responsible for the Post-Cardiac Arrest Syndrome, post-cardiac arrest brain injury. In 2003 therapeutic hypothermia was first recommended by the International Liaison Committee on Resuscitation for having demonstrated a decrease in mortality and being neuroprotective. However, in 2013 new studies have called into question a previously proposed recommendation, suggesting that there is no benefit in terms of temperature, and that temperature should be only controlled to avoid states of hyperthermia, which are associated with worse prognosis.
Out-of-hospital cardiac arrest is one of the leading causes of death in developed countries, and even after a successful resuscitation, it is still responsible for high mortality and morbidity. A fast act before cardiac arrest will be determinant for the prognosis of the patient, however it is important to treat the patient even after return of spontaneous circulation to avoid lesions that occur during the Post-Cardiac Arrest Syndrome. Therapeutic hypothermia/Target Temperature Management is one of the available therapeutic options that seeks to minimize one of the mechanisms responsible for the Post-Cardiac Arrest Syndrome, post-cardiac arrest brain injury. In 2003 therapeutic hypothermia was first recommended by the International Liaison Committee on Resuscitation for having demonstrated a decrease in mortality and being neuroprotective. However, in 2013 new studies have called into question a previously proposed recommendation, suggesting that there is no benefit in terms of temperature, and that temperature should be only controlled to avoid states of hyperthermia, which are associated with worse prognosis.
Descrição
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2017
Palavras-chave
Paragem cárdio-respiratória Síndrome pós-paragem cárdio-respiratória Hipotermia Terapêutica/controlo da temperatura
