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Abstract(s)
A psoríase é uma doença crónica que afeta, aproximadamente, 2 a 3% da população mundial. A sua etiologia é multifatorial resultante da interação entre fatores genéticos, imunológicos e ambientais. Esta doença é caracterizada pelo aparecimento de placas avermelhadas e escamosas na pele, que resultam de uma elevada proliferação e anormal diferenciação de queratinócitos. As lesões variam na sua extensão e gravidade podendo, em casos mais graves, estar presentes em áreas extensas do corpo, afetar as articulações e levar ao aparecimento de outras comorbilidades. Estes fatores representam assim, um impacto negativo no bem-estar e qualidade de vida das pessoas com a doença. A sua terapêutica convencional consiste na utilização crónica de agentes tópicos, sistémicos e biológicos com acentuados efeitos nefastos para a saúde o que, muitas vezes, leva os doentes a uma baixa adesão à terapêutica, o que constitui um impedimento ao sucesso da mesma. Atualmente existe um maior interesse, por parte da população em geral, na procura e utilização de recursos naturais com ação terapêutica que sejam não só eficazes, como possibilitem uma utilização a longo prazo mais segura. Além disso, fatores como o alto custo dos medicamentos sintéticos e a dificuldade no acesso à assistência médica contribuem também para esta tendência. Os produtos à base de plantas e produtos vegetais são utilizados desde a antiguidade, em todo o mundo, no tratamento de diversas patologias, entre as quais as doenças dermatológicas. Um número crescente de estudos têm vindo a ser desenvolvidos, nos últimos anos, em consequência do potencial terapêutico que algumas dessas plantas e produtos vegetais evidenciaram ter. No entanto, ainda são escassos os estudos clínicos e toxicológicos que avaliem, com clareza, a sua eficácia e segurança. É por este motivo, de extrema importância, a realização de mais investigação e ensaios clínicos devidamente controlados que permitam aferir rigorosamente o real valor desta terapêutica. Neste artigo de revisão bibliográfica serão identificadas dez espécies de plantas e produtos vegetais com potenciais benefícios na terapêutica tópica da psoríase. Estas espécies serão analisadas, de acordo com os estudos já publicados, pelas suas características, mecanismos de ação, eficácia e possíveis efeitos adversos.
Psoriasis is a chronic disease that affects, approximately, 2-3% of the world's population. Its etiology is multifactorial resulting from the interaction between genetic, immunological and environmental factors. This disease is characterized by the appearance of red and scaly skin patches resulting from high proliferation and abnormal differentiation of keratinocytes. Lesions differ in extent and severity and, in more severe cases, can cover large areas of the body, affecting the joints, and promote the emergence of comorbidities. These factors have a negative impact on people’s well-being and their life quality. The conventional therapy consists in long term use of topical, systemic and biological agents with severe adverse side effects for the health which often leads to poor therapy’s adherence and success. Nowadays, there is a growing public interest in the search for and use of natural resources with therapeutic action that are not only effective but also safer in the long term. Moreover, the high cost of synthetic drugs and the difficulty in accessing medical care also contribute to this trend. Herbal products have been used around the world since ancient times in the treatment of various pathologies, including dermatological diseases. Over the past few years, as a result of the therapeutic potential, some plants and herbal products have shown to have an increasing number of studies have been conducted. However, there is still a lack of clinical and toxicological studies that clearly assess its efficacy and safety. For this reason, is extremely important to develop more investigation and clinical trials properly controlled, so as to accurately assess the real value of this therapy. In this literature review will be identified ten species of plants and herbal products with potential benefits in the topical treatment of psoriasis. These species will be analyzed, according to studies already published, for their characteristics, action mechanisms, efficacy and adverse side effects.
Psoriasis is a chronic disease that affects, approximately, 2-3% of the world's population. Its etiology is multifactorial resulting from the interaction between genetic, immunological and environmental factors. This disease is characterized by the appearance of red and scaly skin patches resulting from high proliferation and abnormal differentiation of keratinocytes. Lesions differ in extent and severity and, in more severe cases, can cover large areas of the body, affecting the joints, and promote the emergence of comorbidities. These factors have a negative impact on people’s well-being and their life quality. The conventional therapy consists in long term use of topical, systemic and biological agents with severe adverse side effects for the health which often leads to poor therapy’s adherence and success. Nowadays, there is a growing public interest in the search for and use of natural resources with therapeutic action that are not only effective but also safer in the long term. Moreover, the high cost of synthetic drugs and the difficulty in accessing medical care also contribute to this trend. Herbal products have been used around the world since ancient times in the treatment of various pathologies, including dermatological diseases. Over the past few years, as a result of the therapeutic potential, some plants and herbal products have shown to have an increasing number of studies have been conducted. However, there is still a lack of clinical and toxicological studies that clearly assess its efficacy and safety. For this reason, is extremely important to develop more investigation and clinical trials properly controlled, so as to accurately assess the real value of this therapy. In this literature review will be identified ten species of plants and herbal products with potential benefits in the topical treatment of psoriasis. These species will be analyzed, according to studies already published, for their characteristics, action mechanisms, efficacy and adverse side effects.
Description
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019
Keywords
Psoríase Plantas medicinais Fitoterapia Plantas terapêuticas Tratamento tópico Mestrado Integrado - 2019