Two new diterpenoids from Plectranthus species

Simões, Maria de Fátima; Rijo, Patrícia; Duarte, Aida; Barbosa, Diana; Matias, Diogo; Delgado, Joana; Cirilo, Nádia; Rodríguez, Benjamín

http://hdl.handle.net/10451/3937

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Authors

Simões, Maria de Fátima

Abstract(s)

Two new diterpenoids, ent-7α-acetoxy-15-beyeren-18-oic acid and (13S,15S)-6β,7α,12α,19-tetrahydroxy-13β,16-cyclo-8-abietene-11,14-dione, have been isolated from Plectranthus saccatus and Plectranthus porcatus, respectively, and their structures were established by 1D and 2D NMR spectroscopic studies. The new diterpenes showed no activity against Gram-negative bacteria and Candida albicans (yeast strain). Among Gram-positive bacteria, the lower MIC value was 62.50 μg/ml for the abietane derivative against Staphylococcus aureus ATCC 6538.