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Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

2017Artigo científico Acesso aberto
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dc.contributor.authorRocha, Cheila
dc.contributor.authorDuarte, Joana
dc.contributor.authorBorrego, Pedro
dc.contributor.authorCalado, Rita
dc.contributor.authorMarcelino, José Maria
dc.contributor.authorTendeiro, Rita
dc.contributor.authorValadas, Emília
dc.contributor.authorSousa, Ana Espada
dc.contributor.authorTaveira, Nuno
dc.date.accessioned2023-11-02T14:22:45Z
dc.date.available2023-11-02T14:22:45Z
dc.date.issued2017
dc.description.abstractPotent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1097/QAD.0000000000001661pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/29232
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
dc.subjectHIV-2; Antibodies;pt_PT
dc.titlePotency of HIV-2-specific antibodies increase in direct association with loss of memory B cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-FAR%2F115290%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-EPI%2F122400%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5646-ICCMS/PIC%2FIC%2F82712%2F2007/PT
oaire.citation.endPage2433pt_PT
oaire.citation.issue17pt_PT
oaire.citation.startPage2431pt_PT
oaire.citation.titleAIDSpt_PT
oaire.citation.volume31pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5646-ICCMS
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication93cc0c44-979a-4526-ae05-72aee7241743
relation.isProjectOfPublicationa9ec203b-9f69-476e-8c74-d4ba32d8a79c
relation.isProjectOfPublicationc80a37e1-7f5f-494a-962d-7eb5e5aa99ef
relation.isProjectOfPublication.latestForDiscoverya9ec203b-9f69-476e-8c74-d4ba32d8a79c

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