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Evidência científica sobre o uso de ácido hialurónico no tratamento da disfunção temporo-mandibular
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O ácido hialurónico, polissacarídeo de elevado peso molecular produzido por células sinoviais, encontra-se presente em elevadas concentrações na cartilagem e fluido sinovial, exercendo, graças às suas propriedades viscoelásticas, um importante papel na lubrificação e manutenção das articulações. Com esta monografia pretende-se determinar se existe actualmente evidência científica que suporte o uso de ácido hialurónico como forma de tratamento da disfunção temporo-mandibular. Como tal, foi realizada uma pesquisa bibliográfica até Maio de 2011 nas seguintes bases de dados: PubMed / MEDLINE. Dos artigos científicos encontrados durante a pesquisa bibliográfica, seleccionaram-se 20 estudos com relevância científica para o objectivo do presente trabalho. Conclui-se que a injecção intra-articular de ácido hialurónico em pacientes com disfunção temporo-mandibular poderá levar a uma melhoria nos sinais e sintomas descritos. No entanto, são necessários mais estudos de elevada qualidade que suportem o uso de AH em pacientes com DTM e que permitam estabelecer conclusões efectivas no que diz respeito ao efeito terapêutico desta substância.
Hyaluronic acid, a high molecular weight polysaccharide produced by synovial cells, is present in high concentrations in cartilage and synovial fluid, exercising, thanks to its viscoelastic properties, an important role in the maintenance and lubrication of the joints. The aim of this monograph is to determine if there is currently scientific evidence to support the use of hyaluronic acid as a treatment of temporomandibular dysfunction. As such, a literature search to May 2011 was performed in the following databases: PubMed / MEDLINE. Of all scientific articles found during the literature search, 20 studies were selected with scientific relevance to the aim of the present work. It is concluded that intra-articular injection of hyaluronic acid in patients with temporomandibular dysfunction can lead to an improvement in signs and symptoms. However, more high quality studies that support the use of hyaluronic acid in patients with temporomandibular dysfunction are absolutely needed in order to establish the true therapeutic effects of this substance.
Hyaluronic acid, a high molecular weight polysaccharide produced by synovial cells, is present in high concentrations in cartilage and synovial fluid, exercising, thanks to its viscoelastic properties, an important role in the maintenance and lubrication of the joints. The aim of this monograph is to determine if there is currently scientific evidence to support the use of hyaluronic acid as a treatment of temporomandibular dysfunction. As such, a literature search to May 2011 was performed in the following databases: PubMed / MEDLINE. Of all scientific articles found during the literature search, 20 studies were selected with scientific relevance to the aim of the present work. It is concluded that intra-articular injection of hyaluronic acid in patients with temporomandibular dysfunction can lead to an improvement in signs and symptoms. However, more high quality studies that support the use of hyaluronic acid in patients with temporomandibular dysfunction are absolutely needed in order to establish the true therapeutic effects of this substance.
Descrição
Tese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2011
Palavras-chave
Oclusão dentária Teses de mestrado - 2011