A carregar...
Publicação
Aplicação dos sais biliares em farmácia
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 961.24 KB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
A história do conhecimento da física, da química e da biologia dos ácidos biliares conta com muitas décadas, sendo atualmente uma família de moléculas com uma enorme importância nas mais variadas funções: na digestão e solubilização de nutrientes lipofílicos e fármacos a nível do intestino e também muito promissoras no que diz respeito à sinalização celular, através da sua interação com determinados recetores.
Com efeito, os ácidos biliares apresentam propriedades físico-químicas e biológicas muito peculiares que lhes conferem um elevado potencial de aplicação nos campos biomédicos e farmacêuticos. No campo farmacêutico, os sais biliares foram empregues com base em dois conceitos diferentes: o primeiro conceito explorou as funções metabólicas e homeostáticas dos sais biliares na modulação de uma doença, enquanto o segundo utilizou o seu potencial para modificar as características na distribuição de um fármaco, tendo-se revelado promissores sistemas de transporte de fármacos, envolvendo particularmente a nanotecnologia.
A presente monografia estuda o potencial clínico dos ácidos biliares, enquanto agentes com propriedades terapêuticas, nas mais diversas patologias, tais como doenças neurodegenerativas, oftalmológicas, na síndrome metabólica, em doenças hepáticas e ainda enquanto agentes antimicrobianos e antitumorais. Por outro lado, pretende-se consolidar as aplicações dos mesmos enquanto sistemas de transporte de fármacos, principalmente através de nanoestruturas, como é o caso das micelas mistas, dos bilossomas e dos conjugados químicos que, por sua vez, são capazes de alterar as propriedades de um fármaco, otimizando a sua biodisponibilidade e constantando a pluralidade de aplicação dos ácidos biliares nas mais diversas patologias.
The history's knowledge of the physics, chemistry, and biology of bile acids has been going on for many decades, is now a family of molecules with enormous importance in the most varied functions: in the digestion and solubilization of lipophilic nutrients and drugs in the intestine and also very promising concerning cell signaling, through their interaction with certain receptors. Indeed, bile acids have very peculiar physical-chemical and biological properties that give them a high potential for application in the biomedical and pharmaceutical fields. In the pharmaceutical field, bile salts were used based on two different concepts: the first concept explored the metabolic and homeostatic functions of bile salts in modulating a disease, while the second uses its potential to modify the characteristics in the distribution of a drug, promising drug transport systems have been highlighted, particularly involving nanotechnology. The present monograph studies the clinical potential of bile acids, as agents with therapeutic properties, in the most diverse pathologies, such as neurodegenerative diseases, ophthalmological diseases, metabolic syndrome, liver diseases, and even as antimicrobial and antitumor agents. On the other hand, it is intended to consolidate the applications of bile acids as drug transport systems, mainly through nanostructures, as is the case of bilosomes, mixed micelles, and chemical conjugates that, in turn, can alter the pharmacokinetic properties of the drug and improve its bioavailability thus enabling a suitable targeted therapy of numerous diseases.
The history's knowledge of the physics, chemistry, and biology of bile acids has been going on for many decades, is now a family of molecules with enormous importance in the most varied functions: in the digestion and solubilization of lipophilic nutrients and drugs in the intestine and also very promising concerning cell signaling, through their interaction with certain receptors. Indeed, bile acids have very peculiar physical-chemical and biological properties that give them a high potential for application in the biomedical and pharmaceutical fields. In the pharmaceutical field, bile salts were used based on two different concepts: the first concept explored the metabolic and homeostatic functions of bile salts in modulating a disease, while the second uses its potential to modify the characteristics in the distribution of a drug, promising drug transport systems have been highlighted, particularly involving nanotechnology. The present monograph studies the clinical potential of bile acids, as agents with therapeutic properties, in the most diverse pathologies, such as neurodegenerative diseases, ophthalmological diseases, metabolic syndrome, liver diseases, and even as antimicrobial and antitumor agents. On the other hand, it is intended to consolidate the applications of bile acids as drug transport systems, mainly through nanostructures, as is the case of bilosomes, mixed micelles, and chemical conjugates that, in turn, can alter the pharmacokinetic properties of the drug and improve its bioavailability thus enabling a suitable targeted therapy of numerous diseases.
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2020, Universidade de Lisboa, Faculdade de Farmácia.
Palavras-chave
Sais biliares Sistemas de veiculação de fármacos Absorção intestinal Biodisponibilidade Mestrado integrado - 2020