A carregar...
Publicação
An easy and stereoselective rearrangement of an abietane diterpenoid into a bioactive microstegiol derivative
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 392.3 KB | Adobe PDF |
Orientador(es)
Resumo(s)
Parvifloron D was isolated from Plectranthus ecklonii together with sugiol and mixtures of β-sitosterol and stigmasterol and ursolic and oleanolic acids. Treatment of parvifloron D [2α-(4-hydroxy)benzoyloxy-11-hydroxy-5,7,9(11),13-abietatetraen-12-one] with acid-washed molecular sieves gave the microstegiol derivative 2β-(4-hydroxy)benzoyloxy-11β-hydroxy-4(5 → 11),20(10 → 5)diabeo-5(10),6,8,13-abietatetraen-12-one in a moderate yield (26%). The new microstegiol derivative inhibited the growth of some Staphylococcus and Enterococcus species with significant MIC values ranging from 3.91 to 7.81 μg/ml.
Descrição
Palavras-chave
Plectranthus ecklonii Labiatae Abietanes Rearranged abietanes Microstegiol derivative Acid-washed molecular sieves as catalyst
Contexto Educativo
Citação
Phytochemistry Letters. December 2010, 3(4) 234-237