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Análise de biomarcadores urinários na doença poliquística renal autossómica dominante
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Orientador(es)
Resumo(s)
A doença poliquística renal autossómica dominante (DPRAD) manifesta-se pela progressiva formação de quistos renais, aumentando em número e tamanho, pelo aparecimento de fibrose intersticial, culminando num declínio da função renal (DFR) e, em última instância, na necessidade de terapia de substituição renal.
Este estudo consistiu na caracterização de uma população de pacientes com DPRAD e na análise dos biomarcadores urinários (α-glutationo s-transferase (α-GST), π-glutationo s-transferase (π-GST), haptoglobina (Hp)), correlacionando-os com a gravidade da doença avaliada pela estimativa da do filtrado glomerular (TFG) e pelo volume renal (VR), calculado pelo algoritmo proposto pela Mayo Clinic. I,Figura 5
Os resultados mostram que os níveis da Hp e α-GST estão associados ao aumento da creatinina sérica. Estes biomarcadores parecem ser uteis na deteção da instalação precoce da disfunção renal, o que poderá contribuir para a identificação de candidatos a terapêuticas inovadoras como o tolvaptan, de forma a retardar a progressão da DPRAD.
Autossomal dominant polycystic kidney (ADPKD) disease is characterized by the progressive development of renal cysts, which grow in size and number, and by the formation of interstitial fibrosis. This leads to a renal function decline and, ultimately, in the need for renal replacement therapy. The search for new urinary biomarkers may contribute to improving the precision in early detection of renal function decline in ADPKD. The objective of this study was to characterize a population of ADPKD patients and, posteriorly, to analyze the urinary biomarkers alpha-glutathione s-transferase (α-GST), haptoglobin (Hp) and correlate them with the severity of the disease by the estimated glomerular filtration rate (GFR) and kidneys’s volume as evaluated by the Mayo Clinic algorithm.I The obtained results show that the levels of Hp and α-GST are associated with serum creatinine increase. The biomarkers seem to be useful in predicting the early onset of renal function decline, which might aid in the selection of candidates for innovative therapeutics like tolvaptan, contributing to the decline of DPRAD progression rate.
Autossomal dominant polycystic kidney (ADPKD) disease is characterized by the progressive development of renal cysts, which grow in size and number, and by the formation of interstitial fibrosis. This leads to a renal function decline and, ultimately, in the need for renal replacement therapy. The search for new urinary biomarkers may contribute to improving the precision in early detection of renal function decline in ADPKD. The objective of this study was to characterize a population of ADPKD patients and, posteriorly, to analyze the urinary biomarkers alpha-glutathione s-transferase (α-GST), haptoglobin (Hp) and correlate them with the severity of the disease by the estimated glomerular filtration rate (GFR) and kidneys’s volume as evaluated by the Mayo Clinic algorithm.I The obtained results show that the levels of Hp and α-GST are associated with serum creatinine increase. The biomarkers seem to be useful in predicting the early onset of renal function decline, which might aid in the selection of candidates for innovative therapeutics like tolvaptan, contributing to the decline of DPRAD progression rate.
Descrição
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2019
Palavras-chave
Rins poliquísticos Biomarcadores urinários Progressão Doença poliquística renal autossómica dominante Nefrologia