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1-Deoxysphingolipids

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dc.contributor.authorLone, M.A.
dc.contributor.authorSantos, Tânia
dc.contributor.authorAlecu, I.
dc.contributor.authorSilva, Liana C.
dc.contributor.authorHornemann, T.
dc.date.accessioned2025-08-15T00:27:03Z
dc.date.available2025-08-15T00:27:03Z
dc.date.issued2019
dc.description.abstractSphingolipids (SLs) are fundamental components of eukaryotic cells. 1-Deoxysphingolipids differ structurally from canonical SLs as they lack the essential C1-OH group. Consequently, 1-deoxysphingolipids cannot be converted to complex sphingolipids and are not degraded over the canonical catabolic pathways. Pathologically elevated 1-deoxySLs are involved in several disease conditions. Within this review, we will provide an up-to-date overview on the metabolic, physiological and pathophysiological aspects of this enigmatic class of "headless" sphingolipids.pt_PT
dc.description.sponsorshipThe authors acknowledge funding from the Swiss National Foundation SNF (Project 31003A_153390/1); the Herzog Egli Foundation; the Rare Disease Initiative Zurich (“radiz”, Clinical Research Priority Program for Rare Diseases, University of Zurich) (TH) and the Fundação para a Ciência e a Tecnologia (FCT), Portugal grant references PTDC/BBB-BQB/3710/2014, SFRH/BD/102933/2014 to T.S and Investigador FCT to L.C. Silva (IF/00437/2014) (LS).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.bbalip.2018.12.013pt_PT
dc.identifier.issn1388-1981
dc.identifier.urihttp://hdl.handle.net/10400.5/102934
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationProject 31003A_153390/1pt_PT
dc.relationBiological and biophysical properties of atypical sphingolipids: implications to physiology and pathophysiology
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1388198118303172pt_PT
dc.subjectAnimalspt_PT
dc.subjectEukaryotapt_PT
dc.subjectGene Regulatory Networkspt_PT
dc.subjectHumanspt_PT
dc.subjectMolecular Structurept_PT
dc.subjectSphingolipidspt_PT
dc.title1-Deoxysphingolipidspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/BBB-BQB/3710/2014
oaire.awardNumberSFRH/BD/102933/2014
oaire.awardTitleBiological and biophysical properties of atypical sphingolipids: implications to physiology and pathophysiology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBBB-BQB%2F3710%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F102933%2F2014/PT
oaire.citation.endPage521pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage512pt_PT
oaire.citation.titleBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipidspt_PT
oaire.citation.volume1864pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamOE
person.familyNameda Cunha Branco dos Santos
person.familyNameSilva
person.givenNameTânia
person.givenNameLiana
person.identifier664142
person.identifier.orcid0000-0002-4650-0153
person.identifier.orcid0000-0003-1311-0770
person.identifier.ridA-3025-2011
person.identifier.scopus-author-id57194389779
person.identifier.scopus-author-id8282140100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication65524d87-500f-4f1b-ac2c-1b3521a1fd55
relation.isAuthorOfPublication.latestForDiscovery4222e1ff-85c3-4db7-a071-0007354f855c
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