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Advisor(s)
Abstract(s)
O aumento do consumo de suplementos alimentares em todo o mundo é notável, assim
como o aumento no consumo de medicamentos. A primeira é resultante, não só pela
consciencialização sobre saúde e bem-estar e pela procura de colmatar deficiências
nutricionais, como também devido aos meios de comunicação social. Já a segunda
deve-se principalmente ao envelhecimento da população e ao aumento da prevalência
de doenças crónicas.
Desta forma é cada vez mais importante explorar as interações que podem ocorrer entre
suplementos alimentares e medicamentos, para que possa ser feita uma utilização
consciente e segura de ambos, sem que haja qualquer risco para o consumidor. Por isso,
neste trabalho estão descritas as principais interações documentadas e uma breve
análise das mesmas, abrangendo os suplementos à base de vitaminas, minerais, plantas,
coenzimas, hormonas, probióticos, ácidos gordos polinsaturados e fibras e, também,
diversos medicamentos de diversas classes farmacológicas como os anticoagulantes,
antiplaquetários, antiarrítmicos, anti-hipertensivos, hipolipemiantes, hipoglicemiantes,
antineoplásicos, imunossupressores, antibióticos, antirretrovirais, antiepiléticos,
contracetivos orais, hormonas de substituição, antiparkinsónicos, benzodiazepinas,
antidepressivos tricíclicos, antifúngicos e anti-inflamatórios.
Para além de interações é abrangida, de uma forma breve, a legislação em vigor para a
introdução no mercado de ambos os medicamentos e os suplementos alimentares de
forma a compará-las e dar a perceber que não possuem o mesmo tipo de controlo e,
portanto, não irão ter o mesmo tipo de segurança na sua utilização.
Por fim, destaca-se a importância da educação dos doentes sobre um uso informado e
supervisionado deste tipo de produtos, incluindo o seu médico e também farmacêutico,
para que haja a maximização dos benefícios terapêuticos minimizando os riscos
associados.
The increase in the consumption of dietary supplements around the world is notable, as is the increase in the consumption of medicines. The first is the result, not only of awareness about health and well-being and the search to overcome nutritional deficiencies, but also due to the media. The second is mainly due to the aging of the population and the increase in the prevalence of chronic diseases. Therefore, it is increasingly important to explore the interactions that may occur between dietary supplements and medicines, so that both can be used consciously and safely, without any risk to the consumer. Therefore, this work describes the main documented interactions and a brief analysis of them, covering supplements based on vitamins, minerals, plants, coenzymes, hormones, probiotics, polyunsaturated fatty acids and fibers, as well as various medicins from different pharmacological classes such as anticoagulants, antiplatelets, antiarrhythmics, antihypertensives, lipid-lowering agents, hypoglycemic agents, antineoplastics, immunosuppressants, antibiotics, antiretrovirals, antiepileptics, oral contraceptives, replacement hormones, antiparkinsonian agents, benzodiazepines, tricyclic antidepressants, antifungals and anti-inflammatories. In addition to interactions, the legislation in force for the introduction of both medicines and dietary supplements onto the market is briefly covered in order to compare them and make it clear that they do not have the same type of control and, therefore, they will not have the same type of security when using them. Finally, the importance of educating patients about the informed and supervised use of this type of products is highlighted, including their doctor and pharmacist, so that the therapeutic benefits can be maximized while minimizing the associated risks.
The increase in the consumption of dietary supplements around the world is notable, as is the increase in the consumption of medicines. The first is the result, not only of awareness about health and well-being and the search to overcome nutritional deficiencies, but also due to the media. The second is mainly due to the aging of the population and the increase in the prevalence of chronic diseases. Therefore, it is increasingly important to explore the interactions that may occur between dietary supplements and medicines, so that both can be used consciously and safely, without any risk to the consumer. Therefore, this work describes the main documented interactions and a brief analysis of them, covering supplements based on vitamins, minerals, plants, coenzymes, hormones, probiotics, polyunsaturated fatty acids and fibers, as well as various medicins from different pharmacological classes such as anticoagulants, antiplatelets, antiarrhythmics, antihypertensives, lipid-lowering agents, hypoglycemic agents, antineoplastics, immunosuppressants, antibiotics, antiretrovirals, antiepileptics, oral contraceptives, replacement hormones, antiparkinsonian agents, benzodiazepines, tricyclic antidepressants, antifungals and anti-inflammatories. In addition to interactions, the legislation in force for the introduction of both medicines and dietary supplements onto the market is briefly covered in order to compare them and make it clear that they do not have the same type of control and, therefore, they will not have the same type of security when using them. Finally, the importance of educating patients about the informed and supervised use of this type of products is highlighted, including their doctor and pharmacist, so that the therapeutic benefits can be maximized while minimizing the associated risks.
Description
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2024, Universidade de Lisboa, Faculdade de Farmácia.
Keywords
Interação Suplementos alimentares Medicamentos Eficácia Mestrado integrado - 2024