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Influência dos polimorfismos da IL-1 na doença periodontal
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Introdução: A periodontite é uma doença infecciosa associada à aumulação de placa bacteriana levando à destruição dos tecidos de suporte do dente. No entanto, embora centenas de milhões de bactérias colonizem continuamente as superfícies dentárias ao longo da vida, nem todos os indivíduos apresentam evidências de destruição periodontal. Factores relacionados com a predisposição do indivíduo para manifestar a doença podem influenciar o início, a progressão e as características desta desordem associada à placa bacteriana. Objetivo: O presente trabalho tem como objectivo realizar uma revisão da literatura relativa à associação entre os polimorfismos da IL-1 e a severidade e progressão da doença periodontal crónica. Metodologia: Foi realizada pesquisa manual em fontes de informação secundárias (livros e revistas cientificas) disponíveis na biblioteca da Faculdade de Medicina Dentária da Universidade de Lisboa e na base de dados primária MEDLINE (através do motor de busca PubMed) até Março de 2015, filtrada para língua inglesa, utilizando a seguinte palavra chave: ("periodontal disease" OR "periodontitis") AND ("interleukin-1" OR "IL-1") AND ("polymorphism" OR "haplotypes"). Resultados: Foram seleccionados 31 artigos, dos quais 20 estudos caso-controlo, 3 estudos observacionais transversais, 3 meta-análises, 2 revisões sistemáticas e 2 revisões narrativas. De uma forma geral 12 estudos encontraram correlação dos polimorfismos da IL-1A (-889), IL-1A (+4845), IL-1B (-511), IL-1B (-3954), IL-1RN VNTR e principalmente do genótipo composto com a doença periodontal crónica. No entanto, outros resultados controversos dificultaram a obtenção de resultados devido à variabilidade do status tabágico, idade e etnias entre e inter-estudos. Conclusão: Esta revisão sugere evidências de associação entre os polimorfismos da IL-1 e a severidade e progressão da doença periodontal crónica. No entanto, é necessário a realização de mais estudos com ajuste das principais variáveis de confusão (status tabágico, quantidade de placa bacteriana, idade e etnia), bem como estratificação do fenótipo clínico de forma a obter resultados comparáveis entre estudos.
Introduction: Periodontitis is an infectious disease associated with plaque accumulation, leading to the destruction of the tooth supporting tissue. However, although hundreds of millions of bacteria colonize the tooth surfaces continuously throughout life, not all individuals have evidence of periodontal destruction. Factors related to the predisposition of the individual to manifest the disease can influence the onset, progression and characteristics of this disorder associated with bacterial plaque. Objective: This study aims to carry out a review of the literature on the association between IL -1 polymorphisms and the severity and progression of chronic periodontal disease. Methodology: A manual search was performed on secondary information sources (books and scientific journals ) available in the library of the Faculty of Dental Medicine, University of Lisbon and primary database MEDLINE (via PubMed search engine ) until March 2015 , filtered for English language, using the following password: ("periodontal disease" OR "periodontitis") AND ("interleukin -1" OR "IL -1") AND (" polymorphism" OR "haplotypes"). Results: 31 articles were selected, including 20 case- control studies, 3 cross observational studies, 3 Meta-analyzes, 2 systematic reviews and two 2 narrative reviews. Generally, 12 studies found a correlation of polymorphisms of IL -1A ( -889 ) , IL -1A ( +4845 ) IL -1B ( -511 ) IL -1B ( -3954 ) , IL- 1RN VNTR and especially the genotype compound of chronic periodontal disease. However, other controversial results, made difficult to obtain results due to variability in smoking status, age and ethnic groups among and between studies. Conclusion: This review suggests evidence of an association between IL -1 polymorphisms and the severity and progression of chronic periodontal disease. However, further studies with adjustment to the main confounding variables (smoking status, amount of plaque, age and ethnicity) is required, as well as, stratification of clinical phenotype in order to obtain comparable results between studies.
Introduction: Periodontitis is an infectious disease associated with plaque accumulation, leading to the destruction of the tooth supporting tissue. However, although hundreds of millions of bacteria colonize the tooth surfaces continuously throughout life, not all individuals have evidence of periodontal destruction. Factors related to the predisposition of the individual to manifest the disease can influence the onset, progression and characteristics of this disorder associated with bacterial plaque. Objective: This study aims to carry out a review of the literature on the association between IL -1 polymorphisms and the severity and progression of chronic periodontal disease. Methodology: A manual search was performed on secondary information sources (books and scientific journals ) available in the library of the Faculty of Dental Medicine, University of Lisbon and primary database MEDLINE (via PubMed search engine ) until March 2015 , filtered for English language, using the following password: ("periodontal disease" OR "periodontitis") AND ("interleukin -1" OR "IL -1") AND (" polymorphism" OR "haplotypes"). Results: 31 articles were selected, including 20 case- control studies, 3 cross observational studies, 3 Meta-analyzes, 2 systematic reviews and two 2 narrative reviews. Generally, 12 studies found a correlation of polymorphisms of IL -1A ( -889 ) , IL -1A ( +4845 ) IL -1B ( -511 ) IL -1B ( -3954 ) , IL- 1RN VNTR and especially the genotype compound of chronic periodontal disease. However, other controversial results, made difficult to obtain results due to variability in smoking status, age and ethnic groups among and between studies. Conclusion: This review suggests evidence of an association between IL -1 polymorphisms and the severity and progression of chronic periodontal disease. However, further studies with adjustment to the main confounding variables (smoking status, amount of plaque, age and ethnicity) is required, as well as, stratification of clinical phenotype in order to obtain comparable results between studies.
Descrição
Tese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2015
Palavras-chave
Doença periodontal Polimorfismos Teses de mestrado - 2015