Publication
NAFLD nutritional management: results from a multidisciplinary approach
| dc.contributor.author | Policarpo, Sara | |
| dc.contributor.author | Machado, Mariana | |
| dc.contributor.author | Pires Barreira, David | |
| dc.contributor.author | Cortez-Pinto, Helena | |
| dc.date.accessioned | 2023-02-15T15:07:30Z | |
| dc.date.available | 2023-02-15T15:07:30Z | |
| dc.date.issued | 2022 | |
| dc.description | © 2021 Sociedade Portuguesa de Gastrenterologia Published by S. Karger AG, Basel. This is an Open Access article licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense), applicable to the online version of the article only. Usage and distribution for commercial purposes requires written permission. | pt_PT |
| dc.description.abstract | Introduction: Lifestyle changes are the mainstay treatment of nonalcoholic fatty liver disease (NAFLD). We aimed to assess the magnitude of weight loss in a group of NAFLD patients followed on a combined lifestyle intervention by a multidisciplinary team. Methods: Patients were assessed before and after a 12-month dietary intervention (Mediterranean diet aiming at weight loss). Patients who received a structured dietary plan along with general lifestyle recommendations were designated as the multidisciplinary treatment (MdT) group. Patients who declined follow-up still received general lifestyle recommendations and were designated as the conventional treatment group, being used as a control group. Results: From the 77 patients with documented NAFLD, 31.2% of patients were overweight and 55.8% obese; 66 patients constituted the MdT group and 11 the conventional treatment group. After 3 months, 89% of patients lost weight; at 6 months, 75.4% maintained the weight lost. At 12 months, 65% of patients still decreased their weight, with 92.2% of patients in the MdT group still maintaining a lower weight than baseline versus just 50% in the conventional group (p = 0.008). Only patients in the MdT group presented a weight loss higher than 10% (9.6%; n = 6). At 12 months patients in the MdT group presented an average reduction of 4.2 kg versus a reduction of just 0.6 kg in the conventional treatment group (p = 0.016). The MdT group, but not the conventional group, presented significant differences in liver enzymes at 12 months compared to baseline. Conclusion: Adherence to a multidisciplinary approach, compared to management solely by a hepatologist, in NAFLD patients, is effective with greater weight loss after a 12-month follow-up and a lower rate of weight gain recurrence. | pt_PT |
| dc.description.abstract | Introdução: Mudanças no estilo de vida são a base do tratamento do fígado gordo não-alcoólico (FGNA). O nosso objetivo foi avaliar a magnitude da perda de peso num grupo de doentes com FGNA sujeitos a intervenção nutricional e acompanhados por uma equipa multidisciplinar. Métodos: Os doentes foram avaliados antes e após uma intervenção nutricional de 12 meses (dieta mediterrânica com objetivo de perda ponderal). Os doentes que recusaram follow-up multidisciplinar, receberam recomendações gerais de estilo de vida e foram designados como grupo de tratamento convencional e usados como comparação com o grupo de tratamento multidisciplinar (MD), que em adição às recomendações gerais, recebeu plano nutricional personalizado. Resultados: Dos 77 pacientes com FGNA documentado, 31.2% dos pacientes estavam em pré-obesidade e 55.8% eram obesos; 66 pacientes constituíram o grupo MD e 11 o grupo de tratamento convencional. Após 3 meses, 89% dos pacientes perderam peso, aos 6 meses, 75.4% mantiveram a perda de peso. Aos 12 meses, 65% dos pacientes ainda diminuíram o seu peso, com 92.2% dos pacientes no grupo MD mantendo um peso inferior ao inicial vs. 50% no grupo convencional (p = 0.008). Apenas os pacientes do grupo MD, conseguiram uma perda de peso superior a 10% (9.6%; n = 6). Aos 12 meses, os pacientes do grupo MD apresentaram redução média de 4.2 kg vs. redução de 0.6 kg no grupo de tratamento convencional (p = 0.016). O grupo MD apresentou diferenças significativas nas enzimas hepáticas aos 12 meses em comparação com valores iniciais. Conclusão: A abordagem multidisciplinar em pacientes com FGNA é efetiva, com maior perda de peso durante o acompanhamento de 12 meses e maior taxa de perda de peso mantida, em comparação com acompanhamento exclusivamente pelo hepatologista. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | GE Port J Gastroenterol. 2021 Dec 1;29(6):401-408 | pt_PT |
| dc.identifier.doi | 10.1159/000519932 | pt_PT |
| dc.identifier.eissn | 2387-1954 | |
| dc.identifier.issn | 2341-4545 | |
| dc.identifier.uri | http://hdl.handle.net/10451/56328 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Karger | pt_PT |
| dc.relation.publisherversion | https://www.karger.com/Journal/Home/272027 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt_PT |
| dc.subject | Dietary intervention | pt_PT |
| dc.subject | Mediterranean diet | pt_PT |
| dc.subject | Multidisciplinary team | pt_PT |
| dc.subject | Nonalcoholic fatty liver disease | pt_PT |
| dc.subject | Weight loss | pt_PT |
| dc.title | NAFLD nutritional management: results from a multidisciplinary approach | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 408 | pt_PT |
| oaire.citation.issue | 6 | pt_PT |
| oaire.citation.startPage | 401 | pt_PT |
| oaire.citation.title | GE - Portuguese Journal of Gastroenterology | pt_PT |
| oaire.citation.volume | 29 | pt_PT |
| person.familyName | Policarpo | |
| person.familyName | Machado | |
| person.familyName | Pires Barreira | |
| person.familyName | Cortez-Pinto | |
| person.givenName | Sara | |
| person.givenName | Mariana | |
| person.givenName | David | |
| person.givenName | Helena | |
| person.identifier | 103277 | |
| person.identifier.ciencia-id | 931F-B799-E0F2 | |
| person.identifier.ciencia-id | A01C-0511-C986 | |
| person.identifier.orcid | 0000-0001-8594-1720 | |
| person.identifier.orcid | 0000-0001-7769-7860 | |
| person.identifier.orcid | 0000-0001-7273-8547 | |
| person.identifier.orcid | 0000-0002-8537-8744 | |
| person.identifier.scopus-author-id | 55915259900 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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