Publicação
Effects of acetylcholine on an animal mode of inflammation
| dc.contributor.author | Silva-Herdade, Ana S. | |
| dc.contributor.author | Saldanha, Carlota | |
| dc.date.accessioned | 2014-03-04T16:06:46Z | |
| dc.date.available | 2014-03-04T16:06:46Z | |
| dc.date.issued | 2013 | |
| dc.description | © 2013 – IOS Press and the authors. All rights reserved | eng |
| dc.description.abstract | Acetylcholinesterase (AChE) is found both on the membranes of neuronal and non-neuronal cells. In this study we performed intravenous administrations of velnacrine (VLN) and acetylcholine (ACh), respectively,AChE inhibitor and substrate, in an animal model of lipopolysaccharide (LPS)-induced inflammation in Wistar rats. Using intravital microscopy the number of rolling and adherent leukocytes in post-capillary venules was monitorized and blood samples were collected for TNF-α plasma concentrations determination. Our results showed that in presence of LPS, ACh has an anti-inflammatory effect, seen by a decrease in TNF-α plasma levels and maintains the number of rolling and adherent leukocytes. The presence of VLN before LPS almost blocked the LPS-induced rolling and TNF-α releasing. Thereby VLN seems to have, like ACh, an anti-inflammatory effect by diminishing TNF-α concentrations. | eng |
| dc.identifier.citation | Clinical Hemorheology and Microcirculation 53 (2013) 209–216 | por |
| dc.identifier.issn | 1386-0291 | |
| dc.identifier.uri | http://dx.doi.org/10.3233/CH-121646 | |
| dc.identifier.uri | http://hdl.handle.net/10451/10672 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | IOS Press | eng |
| dc.subject | Inflammation | eng |
| dc.subject | Acetylcholine | eng |
| dc.subject | TNF-α | eng |
| dc.subject | Velnacrine | eng |
| dc.subject | Rolling leukocytes | eng |
| dc.subject | Intravital microscopy | eng |
| dc.title | Effects of acetylcholine on an animal mode of inflammation | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 216 | por |
| oaire.citation.startPage | 209 | por |
| oaire.citation.title | Clinical Hemorheology and Microcirculation | eng |
| oaire.citation.volume | 53 | por |
| person.familyName | Silva-Herdade | |
| person.familyName | Saldanha | |
| person.givenName | Ana S. | |
| person.givenName | Carlota | |
| person.identifier | 749915 | |
| person.identifier | 53901 | |
| person.identifier.ciencia-id | 6517-B340-F362 | |
| person.identifier.orcid | 0000-0002-3023-1315 | |
| person.identifier.orcid | 0000-0002-5058-2112 | |
| person.identifier.rid | B-2735-2019 | |
| rcaap.rights | closedAccess | por |
| rcaap.type | article | por |
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