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A utilização de gel de poliacrilamida 2,5% em cavalos com osteoartrite : 2 estudos de caso
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Advisor(s)
Abstract(s)
A osteoartrite é a doença articular mais comum em seres humanos e animais, resultando em dor crónica e deficiência motora. Existem inúmeras formas de tratamento da osteoartrite, sendo o tratamento intra articular muito comum. Os fármacos mais utilizados são os corticosteroides, o ácido hialurónico e os glicosaminoglicanos polisulfatados. Mais recentemente surgiram terapêuticas regenerativas, com recurso, por exemplo, à utilização de soro autólogo condicionado, de plasma rico em plaquetas e de células estaminais. Contudo, nenhum tratamento apresenta efeito e eficácia prolongada. Na última década surgiu o gel de poliacrilamida 2,5% que se tornou uma terapêutica de grande interesse para a osteoartrite em cavalos e, inclusivamente, com resultados promissores em medicina humana. Este trabalho engloba dois estudos de caso em cavalos, em que foram feitas administrações intra-articulares de 1ml de gel de poliacrilamida 2,5% em duas quartelas e um boleto, após diagnóstico de osteoartrite. Foi realizada avaliação da claudicação 1 mês após a administração. Foi realizada segunda reavaliação 6 meses após o tratamento. Em um dos casos observou-se melhoria na claudicação ao primeiro mês, tendo o segundo caso evidenciado melhoria clínica aos 6 meses. Os nossos resultados sugerem que a administração intra-articular de gel de poliacrilamida 2,5% poderá ser um tratamento a ter em consideração em casos de osteoartrite em cavalos
ABSTRACT - Osteoarthritis is the most common joint disease in humans and animals, resulting in chronic pain and motor disability - There are numerous treatments for osteoarthritis, with intra-articular treatment being very common. The most used intra-articular medications are corticosteroids, hyaluronic acid, and polysulfated glycosaminoglycans. More recently, regenerative therapies have emerged, such as the use of conditioned autologous serum, platelet-rich plasma, and stem cells. However, no treatment has demonstrated prolonged effects and efficacy. In the last decade, 2.5% polyacrylamide gel has emerged, becoming a highly promising therapy for osteoarthritis in horses, and even shows promising results in human medicine. This study includes two case studies in horses, where intra-articular administrations of 1 ml of 2.5% polyacrylamide gel were performed in two pasterns and one fetlock, following an osteoarthritis diagnosis. Lameness was assessed one month after administration. A second evaluation was conducted 6 months post-treatment. In one case, an improvement in lameness was observed at the first month, while the second case showed clinical improvement at 6 months. Our results suggest that intra-articular administration of 2.5% polyacrylamide gel may be a treatment to consider for osteoarthritis in horses
ABSTRACT - Osteoarthritis is the most common joint disease in humans and animals, resulting in chronic pain and motor disability - There are numerous treatments for osteoarthritis, with intra-articular treatment being very common. The most used intra-articular medications are corticosteroids, hyaluronic acid, and polysulfated glycosaminoglycans. More recently, regenerative therapies have emerged, such as the use of conditioned autologous serum, platelet-rich plasma, and stem cells. However, no treatment has demonstrated prolonged effects and efficacy. In the last decade, 2.5% polyacrylamide gel has emerged, becoming a highly promising therapy for osteoarthritis in horses, and even shows promising results in human medicine. This study includes two case studies in horses, where intra-articular administrations of 1 ml of 2.5% polyacrylamide gel were performed in two pasterns and one fetlock, following an osteoarthritis diagnosis. Lameness was assessed one month after administration. A second evaluation was conducted 6 months post-treatment. In one case, an improvement in lameness was observed at the first month, while the second case showed clinical improvement at 6 months. Our results suggest that intra-articular administration of 2.5% polyacrylamide gel may be a treatment to consider for osteoarthritis in horses
Description
Dissertação de Mestrado Integrado em Medicina Veterinária, área científica de Clínica
Keywords
Gel de poliacrilamida 2,5% Osteoartrite Cavalo Claudicação 2.5% polyacrylamide gel Osteoarthritis Horse Lameness
Pedagogical Context
Citation
Silva GACC. 2025. A utilização de gel de poliacrilamida 2,5% em cavalos com osteoartrite : 2 estudos de caso [dissertação de mestrado]. Lisboa: FMV-Universidade de Lisboa
Publisher
Universidade de Lisboa, Faculdade de Medicina Veterinária