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Efeitos dos estimulantes gustativos e a sua libertação de flúor: estudo piloto
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Objetivos: O presente estudo compara os efeitos produzidos por dois estimulantes gustativos de secreção salivar (EGSS) quanto à capacidade de estimulação do fluxo salivar, potencial erosivo baseado na variação de pH salivar, e quantidade de flúor libertado na saliva durante a exposição. Desenho do estudo: Ensaio clinico aleatório duplamente cego – estudo piloto Materiais e métodos: Uma amostra de 20 estudantes da Faculdade de Medicina Dentária da Universidade de Lisboa, foram recrutados e distribuídos aleatoriamente por dois grupos em cross-over. Todos os participantes foram sujeitos ao EGSS baseado num ácido forte e a outro estimulante composto por um ácido fraco, flúor e xilitol. A colheita da saliva foi obtida pelos métodos pré-estabelecidos nos tempos definidos. Foram medidas, como caraterísticas basais, as capacidade de estimulação mecânica e tamponamento dos voluntários. Posteriormente foi determinado o fluxo salivar, as variações do pH e de libertação de flúor nas amostras através de uma técnica micropotenciométrica e um microelétrodo de pH e flúor respetivamente. Resultados: Os dois EGSS não apresentaram diferenças estatisticamente significativas (P>0,05) quanto à estimulação do fluxo salivar. Comparativamente, o estimulante baseado num ácido fraco obteve, com intervalo de confiança de +/- 95%, uma redução do risco absoluto de 25% [-4,64%;54,64%] para fenómenos potencialmente erosivos e um NNT (número necessário tratar) de 4. Neste estimulante, o pico máximo de libertação de flúor foi aos 4 minutos, sendo libertado 97,09% [86,40% ; 107,77%] da quantidade total advogada pelo fabricante. Conclusão: Os EGSS constituídos por ácido málico, flúor e xilitol mantiveram a eficácia de estimulação salivar dos estimulantes antigos, porém com diminuição do potencial erosivo. Os EGSS mais recentes apresentaram a libertação de quantidades evidentes de flúor para a saliva as quais se coadunam com possíveis efeitos protetores para os tecidos dentários.
Objectives: This study compares the effects between two different gustatory stimulants of salivary secretion (GSSS) when analysing their capacity to stimulate the salivary flow as well their erosive potential based on pH variations and fluoride quantities released in saliva during the exposition to those stimulants. Design: Double blind randomized controlled trial. Materials and methods: 20 students’ sample from Dental Medicine University of Universidade de Lisboa were randomly recruited and distributed between two cross-over groups. All of them were body of two different GSSS applications, one composed by a strong acid and the other one containing a weaker acid, fluoride and xylitol. Salivary collection was obtained through pre-established methods during the defined timings. The capacity for mechanical stimulation and tampon of all voluntaries were measured in an individually basis. Subsequently it was determined the salivary flow, the pH variations and fluoride releases of all samples respectively through microelectrode, pH and fluoride meter technics. Results: The two different GSSS didn’t present any significant statistically differences (P>0,05) when analyzing salivary flow stimulation. Comparing both GSSS, the weaker acid, fluoride and xylitol offered an absolute risk reduction (ARR) for potential erosive phenomena’s of 25% [-4,64% ; 54,64%] and an number needed to treat (NNT) of 4, within ± 95% confidence interval. The same GSSS endorsed a maximum fluoride release point at the 4 minutes, being emitted 97,09% [86,40% ; 107,77%] of the total quantity announced by the producer. Coclusion: The GSSS containing the weaker acid, fluoride and xylitol maintained the salivary stimulation efficiency like older stimulators meanwhile it diminishes the erosive potential. The newest GSSS presented a release of significant fluoride quantities into saliva that go ahead with the possible protector effects of fluoride in dental tissues.
Objectives: This study compares the effects between two different gustatory stimulants of salivary secretion (GSSS) when analysing their capacity to stimulate the salivary flow as well their erosive potential based on pH variations and fluoride quantities released in saliva during the exposition to those stimulants. Design: Double blind randomized controlled trial. Materials and methods: 20 students’ sample from Dental Medicine University of Universidade de Lisboa were randomly recruited and distributed between two cross-over groups. All of them were body of two different GSSS applications, one composed by a strong acid and the other one containing a weaker acid, fluoride and xylitol. Salivary collection was obtained through pre-established methods during the defined timings. The capacity for mechanical stimulation and tampon of all voluntaries were measured in an individually basis. Subsequently it was determined the salivary flow, the pH variations and fluoride releases of all samples respectively through microelectrode, pH and fluoride meter technics. Results: The two different GSSS didn’t present any significant statistically differences (P>0,05) when analyzing salivary flow stimulation. Comparing both GSSS, the weaker acid, fluoride and xylitol offered an absolute risk reduction (ARR) for potential erosive phenomena’s of 25% [-4,64% ; 54,64%] and an number needed to treat (NNT) of 4, within ± 95% confidence interval. The same GSSS endorsed a maximum fluoride release point at the 4 minutes, being emitted 97,09% [86,40% ; 107,77%] of the total quantity announced by the producer. Coclusion: The GSSS containing the weaker acid, fluoride and xylitol maintained the salivary stimulation efficiency like older stimulators meanwhile it diminishes the erosive potential. The newest GSSS presented a release of significant fluoride quantities into saliva that go ahead with the possible protector effects of fluoride in dental tissues.
Descrição
Tese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2011
Palavras-chave
Saúde oral Teses de mestrado - 2011