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Resumo(s)
O glĂșten Ă© o principal constituinte dos cereais mais consumidos no mundo (trigo, centeio e cevada), fazendo parte da base da alimentação humana. Nas Ășltimas dĂ©cadas tem sido associado ao desenvolvimento, agravamento e progressĂŁo de mĂșltiplas doenças autoimunes, tais como a diabetes mellitus tipo 1 e a esclerose mĂșltipla, levantando a hipĂłtese de o glĂșten ser um fator etiopatogĂ©nico de processos imunomediados. A dieta sem glĂșten tem sido adotada de forma especulativa por pessoas com condiçÔes autoimunes nĂŁo existindo, atĂ© Ă data, evidĂȘncia cientĂfica que suporte a sua recomendação. Nesta revisĂŁo Ă© discutida a evidĂȘncia disponĂvel na literatura acerca da associação entre o consumo de glĂșten e o desenvolvimento de autoimunidade, assim como da eficĂĄcia e segurança da dieta sem glĂșten nas vĂĄrias doenças autoimunes.
Gluten is the main component of the most consumed cereals in the world (like wheat, rye and barley) and itâs consumed on a daily basis. In the last decades it has been associated with the development, progression and worsening of multiple autoimmune diseases, such as type 1 diabetes and multiple sclerosis, which raises the hypothesis that gluten might be an etiopathogenic factor in the development of autoimmunity. People with this kind of condition have been using a gluten free diet in a purely speculative way with no scientific evidence supporting its recommendation. In this review itâs discussed the available evidence from the literature concerning the association between gluten consumption and the development of autoimmunity, as well as the efficiency and security of a gluten free diet in some autoimmune pathologies.
Gluten is the main component of the most consumed cereals in the world (like wheat, rye and barley) and itâs consumed on a daily basis. In the last decades it has been associated with the development, progression and worsening of multiple autoimmune diseases, such as type 1 diabetes and multiple sclerosis, which raises the hypothesis that gluten might be an etiopathogenic factor in the development of autoimmunity. People with this kind of condition have been using a gluten free diet in a purely speculative way with no scientific evidence supporting its recommendation. In this review itâs discussed the available evidence from the literature concerning the association between gluten consumption and the development of autoimmunity, as well as the efficiency and security of a gluten free diet in some autoimmune pathologies.
Descrição
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2023
Palavras-chave
GlĂșten Autoimunidade Permeabilidade intestinal Disbiose Dieta sem glĂșten
