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Scilla maderensis, TLC screening and positive inotropic effect of bulb extracts

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dc.contributor.authorDias, Catarina
dc.contributor.authorGraça, João Adriano Borralho
dc.contributor.authorGonçalves, Maria de Lurdes
dc.date.accessioned2011-08-02T11:36:42Z
dc.date.available2011-08-02T11:36:42Z
dc.date.issued2000
dc.description.abstractScilla maderensis Menezes (Hyacinthaceae) is endemic to the Portuguese Archipelago of Madeira. The taxonomic proximity between Scilla L. and Urginea Steinh. genus, and also the knowledge that bulbs of Urginea maritima (L.) Baker (Scilla maritima L.) contain cardiac glycosides of the bufadienolide type, led us to a phytochemical and pharmacological study of S. maderensis. Extracts obtained from the bulbs were screened by TLC and tested in the isolated frog heart preparation. The TLC screening revealed spots with colours and Rf values similar to those obtained for proscillaridin and scillaren A. In the frog heart preparation the extracts showed a positive inotropic effect and toxic doses induced the arrest of the heartbeat in systole. We can conclude that the bulbs of S. maderensis contain substances exerting pharmacological effects on the heart.por
dc.description.sponsorshipCentro de Estudos de Ciências Farmacêuticas (CECF) e Instituto Gulbenkian de Ciênciapor
dc.identifier.citationJournal of Ethnopharmacology, 71 (2000) 487–492por
dc.identifier.issn0378-8741
dc.identifier.urihttp://dx.doi.org/10.1016/S0378-8741(00)00193-8
dc.identifier.urihttp://hdl.handle.net/10451/3846
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0378874100001938por
dc.subjectScilla maderensis Menezespor
dc.subjectHyacinthaceaepor
dc.subjectBulbspor
dc.subjectPositive inotropic effectpor
dc.subjectCardiac glycoside-like effectpor
dc.subjectMadeira Archipelagopor
dc.subjectEndemicpor
dc.subjectVulnerablepor
dc.titleScilla maderensis, TLC screening and positive inotropic effect of bulb extractspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage492por
oaire.citation.startPage487por
oaire.citation.titleJournal of Ethnopharmacologypor
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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