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Scilla maderensis, TLC screening and positive inotropic effect of bulb extracts
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Orientador(es)
Resumo(s)
Scilla maderensis Menezes (Hyacinthaceae) is endemic to the Portuguese Archipelago of Madeira. The taxonomic
proximity between Scilla L. and Urginea Steinh. genus, and also the knowledge that bulbs of Urginea maritima (L.)
Baker (Scilla maritima L.) contain cardiac glycosides of the bufadienolide type, led us to a phytochemical and
pharmacological study of S. maderensis. Extracts obtained from the bulbs were screened by TLC and tested in the
isolated frog heart preparation. The TLC screening revealed spots with colours and Rf
values similar to those
obtained for proscillaridin and scillaren A. In the frog heart preparation the extracts showed a positive inotropic
effect and toxic doses induced the arrest of the heartbeat in systole. We can conclude that the bulbs of S. maderensis
contain substances exerting pharmacological effects on the heart.
Descrição
Palavras-chave
Scilla maderensis Menezes Hyacinthaceae Bulbs Positive inotropic effect Cardiac glycoside-like effect Madeira Archipelago Endemic Vulnerable
Contexto Educativo
Citação
Journal of Ethnopharmacology, 71 (2000) 487–492