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As plantas medicinais na COVID-19:
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Advisor(s)
Abstract(s)
Desde a Antiguidade que as mais diversas plantas medicinais são utilizadas, direta ou indiretamente, na prevenção, tratamento e redução de sintomas das doenças infeciosas, pelas suas inúmeras propriedades farmacológicas.
A COVID-19, doença provocada pela infeção sintomática ao SARS-CoV-2, apresenta atualmente um elevado impacto em toda a sociedade e economia globais, pela sua alta taxa de transmissibilidade e afeção multissistémica, tendo já sido responsável por mais de 6 milhões e 300 mil mortes.
O Objetivo principal desta monografia é assim, fazer um ponto de situação acerca do conhecimento atual e do papel das plantas medicinais na infeção da SARS-CoV-2.
Para o efeito foi efetuada uma pesquisa bibliográfica em repositórios de informação científica, sendo que a maioria dos dados bibliográficos foram referentes aos últimos 4 anos.
Após pesquisa foram identificadas 11 espécies, de relevância terapêutica ou adjuvantes na terapêutica da COVID-19. Destas, 5 foram associadas à mitigação dos sintomas (Lavandula angustifolia, Curcuma longa, Emblica officinalis, Zingiber officinale, Nigella sativa), incluindo o género Echinacea spp., 6 espécies apresentaram atividade antiviral em estudos “in vitro” e “in vivo” (Polygala tenuifolia, Areca catechu, Quercus acutíssima, Scutellaria baicalensis, Glycyrrhiza glabra, Thapsia garganica), 2 associadas à preparação de vacinas (Nicotiana benthamiana, Nicotiana tabacum), 6 associadas a suplementos alimentares e alimentos funcionais (Olea europea, Lavandula angustifólia, Origanum vulgare, Allium sativum, Cinnamomum verum, Hordeum vulgare) e do género Eucalyptus spp., 3 relevantes para aplicações biotecnológicas (Nicotiana tabacum, Zea mays, Oryza sativa).
Esta seleção foi efetuada com base nos resultados de 5 ensaios clínicos e 6 estudos “in vitro” e “in vivo” por nós selecionados, realizados para avaliação do real potencial das diferentes plantas medicinais correspondentes, na prevenção e tratamento da COVID-19.
As plantas parecem apresentar um elevado potencial no tratamento da COVID-19 em conjunto com a terapêutica moderna, o que pode ser muito relevante em determinadas culturas ou realidades económicas. No entanto, mais estudos são necessários para a desenvolvimento e aplicação de medicamentos à base de plantas para tratamento desta patologia.
Since the beginning of time, medicinal plants have been used, directly or indirectly, in the prevention, treatment, and reduction of symptoms of infectious diseases due to their numerous pharmacological properties. COVID-19, a disease caused by the SARS-CoV-2 virus, has a high impact on the entire global society due to its high rate of transmissibility and mortality, having already been responsible for more than 6 million and 300 thousand deaths. The main objective of this thesis is to understand the current knowledge of the role of medicinal plants in SARS-CoV-2 infection treatment and/or prevention. For that, bibliographic research was conducted in scientific information repositories. After research, 11 medicinal species of therapeutic relevance or adjuvants in the treatment of COVID-19 were identified. From these, 5 were associated with symptom mitigation (Lavandula angustifolia, Curcuma longa, Emblica Officinalis, Zingiber officinale, Nigella sativa) including Echinacea spp. , 6 with viricidal capacity and "in vitro" and "in vivo" studies (Polygala tenuifolia, Areca catechu; Quercus acutssima, Scutellaria baicalensis, Glycyrrhiza glabra, Thapsia garganica), 2 associated with the preparation of vaccines (Nicotiana benthamiana, Nicotiana benthamiana, Nicotiana tabacum), 6 associated with food supplements and functional foods (Olea europea, Lavandula angustifolia; Origanum vulgare; Allium sativum, Cinnamomum verum; Hordeum vulgare), from Eucalyptus spp. and 3 were found relevant for biotechnological applications (Nicotiana tabacum; Zea mays; Oryza sativa). This selection was based on the results of 5 clinical trials, 6 "in vitro" and "in vivo" studies that we selected, conducted to evaluate the real potential of the different corresponding medicinal plants in the prevention and treatment of COVID-19. Early conclusions seem to show that plants do have a high potential in the treatment of COVID-19 in conjunction with modern therapy. However, more studies are needed for the development and application of medicines exclusively based on plants.
Since the beginning of time, medicinal plants have been used, directly or indirectly, in the prevention, treatment, and reduction of symptoms of infectious diseases due to their numerous pharmacological properties. COVID-19, a disease caused by the SARS-CoV-2 virus, has a high impact on the entire global society due to its high rate of transmissibility and mortality, having already been responsible for more than 6 million and 300 thousand deaths. The main objective of this thesis is to understand the current knowledge of the role of medicinal plants in SARS-CoV-2 infection treatment and/or prevention. For that, bibliographic research was conducted in scientific information repositories. After research, 11 medicinal species of therapeutic relevance or adjuvants in the treatment of COVID-19 were identified. From these, 5 were associated with symptom mitigation (Lavandula angustifolia, Curcuma longa, Emblica Officinalis, Zingiber officinale, Nigella sativa) including Echinacea spp. , 6 with viricidal capacity and "in vitro" and "in vivo" studies (Polygala tenuifolia, Areca catechu; Quercus acutssima, Scutellaria baicalensis, Glycyrrhiza glabra, Thapsia garganica), 2 associated with the preparation of vaccines (Nicotiana benthamiana, Nicotiana benthamiana, Nicotiana tabacum), 6 associated with food supplements and functional foods (Olea europea, Lavandula angustifolia; Origanum vulgare; Allium sativum, Cinnamomum verum; Hordeum vulgare), from Eucalyptus spp. and 3 were found relevant for biotechnological applications (Nicotiana tabacum; Zea mays; Oryza sativa). This selection was based on the results of 5 clinical trials, 6 "in vitro" and "in vivo" studies that we selected, conducted to evaluate the real potential of the different corresponding medicinal plants in the prevention and treatment of COVID-19. Early conclusions seem to show that plants do have a high potential in the treatment of COVID-19 in conjunction with modern therapy. However, more studies are needed for the development and application of medicines exclusively based on plants.
Description
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2022, Universidade de Lisboa, Faculdade de Farmácia.
Keywords
COVID-19 Ensaios clínicos Plantas medicinais Sintomas Terapêutica Mestrado integrado - 2022