Publicação
Transplantation tolerance: context matters
| dc.contributor.author | Graca, Luis | |
| dc.date.accessioned | 2021-07-27T14:02:25Z | |
| dc.date.available | 2021-07-27T14:02:25Z | |
| dc.date.issued | 2015 | |
| dc.description | Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | pt_PT |
| dc.description.abstract | Costimulation blockade has been one of the most studied strategies to achieve immune tolerance, particularly in transplantation. Yet, in spite of the robust nature of the tolerance-inducing potential of costimulation blockade, a comprehensive understanding of the molecular and cellular mechanisms underlying tolerance induction is still missing. Nevertheless, progress has been continuously made. In this issue of the European Journal of Immunology, Chai et al. [Eur. J. Immunol. 2015. 45: 2017-2027] show that transplantation tolerance induced with an anti-CD154 monoclonal antibody relies on the coexistence of several tolerogenic mechanisms rather than one simple regulatory mechanism. These observations highlight the importance of concerted actions involving multiple pathways, namely apoptosis, acquisition of regulatory cells, or inhibition of proliferation, all of which contribute to the induction and maintenance of robust immune tolerance. A better understanding of these distinct tolerogenic pathways may lead to the development of better tolerance-inducing therapeutics. | pt_PT |
| dc.description.sponsorship | Research in LG laboratory is funded by Fundacao para a Ciencia e Tecnologia FCT/HMSP-ICT/0034/2013 | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Eur J Immunol. 2015 Jul;45(7):1921-1925 | pt_PT |
| dc.identifier.doi | 10.1002/eji.201545762 | pt_PT |
| dc.identifier.eissn | 1521-4141 | |
| dc.identifier.issn | 0014-2980 | |
| dc.identifier.uri | http://hdl.handle.net/10451/49169 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | John Wiley & Sons, Inc. | pt_PT |
| dc.relation.publisherversion | https://onlinelibrary.wiley.com/journal/15214141 | pt_PT |
| dc.subject | Activation-induced cell death | pt_PT |
| dc.subject | CD154 | pt_PT |
| dc.subject | Costimulation blockade | pt_PT |
| dc.subject | Donor-specific transfusion | pt_PT |
| dc.subject | Regulatory T cells | pt_PT |
| dc.subject | Transplantation tolerance | pt_PT |
| dc.title | Transplantation tolerance: context matters | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardNumber | HMSP-ICT/0034/2013 | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/HMSP-ICT%2F0034%2F2013/PT | |
| oaire.citation.endPage | 1925 | pt_PT |
| oaire.citation.issue | 7 | pt_PT |
| oaire.citation.startPage | 1921 | pt_PT |
| oaire.citation.title | European Journal of Immunology | pt_PT |
| oaire.citation.volume | 45 | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| person.familyName | Silva Graca | |
| person.givenName | Luis Ricardo | |
| person.identifier | B-8887-2008 | |
| person.identifier.ciencia-id | 6C19-B162-F561 | |
| person.identifier.orcid | 0000-0001-6935-8500 | |
| person.identifier.scopus-author-id | 36138488700 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 9da841d6-508a-484b-a61e-ee2fab2bc226 | |
| relation.isAuthorOfPublication.latestForDiscovery | 9da841d6-508a-484b-a61e-ee2fab2bc226 | |
| relation.isProjectOfPublication | abff09da-c982-48fa-a2d2-c3d730aca48f | |
| relation.isProjectOfPublication.latestForDiscovery | abff09da-c982-48fa-a2d2-c3d730aca48f |
Ficheiros
Principais
1 - 1 de 1
Miniatura indisponível
- Nome:
- Transplantation_tolerance.pdf
- Tamanho:
- 278.48 KB
- Formato:
- Adobe Portable Document Format