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Authors
Advisor(s)
Abstract(s)
Costimulation blockade has been one of the most studied strategies to achieve immune tolerance, particularly in transplantation. Yet, in spite of the robust nature of the tolerance-inducing potential of costimulation blockade, a comprehensive understanding of the molecular and cellular mechanisms underlying tolerance induction is still missing. Nevertheless, progress has been continuously made. In this issue of the European Journal of Immunology, Chai et al. [Eur. J. Immunol. 2015. 45: 2017-2027] show that transplantation tolerance induced with an anti-CD154 monoclonal antibody relies on the coexistence of several tolerogenic mechanisms rather than one simple regulatory mechanism. These observations highlight the importance of concerted actions involving multiple pathways, namely apoptosis, acquisition of regulatory cells, or inhibition of proliferation, all of which contribute to the induction and maintenance of robust immune tolerance. A better understanding of these distinct tolerogenic pathways may lead to the development of better tolerance-inducing therapeutics.
Description
Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Keywords
Activation-induced cell death CD154 Costimulation blockade Donor-specific transfusion Regulatory T cells Transplantation tolerance
Pedagogical Context
Citation
Eur J Immunol. 2015 Jul;45(7):1921-1925
Publisher
John Wiley & Sons, Inc.