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The clinical spectrum of response to narrowband‐UVB therapy in chronic plaque psoriasis: the lower limbs are the most difficult‐to‐treat body region
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Orientador(es)
Resumo(s)
Psoriasis is a common chronic inflammatory disorder with serious quality of life impairment. Psoriasis Area Severity Index (PASI) and Dermatology Life Quality Index (DLQI) are the most validated scores for accessing psoriasis severity and response to therapy. Plaque psoriasis is the most common form of the disease. In 20% of patients, it is moderate to severe and dictates the need for alternative therapeutic options (ultraviolet (UV) radiation therapy, systemic, or biologic therapy). According to the American Academy of Dermatology and National Psoriasis Foundation guidelines, phototherapy serves as a first-line safe and effective treatment for moderate to severe plaque psoriasis, as monotherapy or combination therapy, for patients requiring more than topical medications and/or those who have contraindications for systemic medications. The two major
types of UV-therapy in psoriasis include photochemotherapy (UVAradiation plus psoralen) and narrowband UVB phototherapy (NBUVB) (UVB-radiation without photosensitizers). Both are effective therapies, but the latter has fewer risks. Though phototherapy is widely used, the literature still lacks evidence regarding the response range of plaque psoriasis, including the distinct clinical response of body segments.
Descrição
© John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Palavras-chave
Phototherapy Psoriasis Ultraviolet Radiation
Contexto Educativo
Citação
Photodermatol Photoimmunol Photomed. 2023 Sep;39(5):529-531
Editora
Wiley