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Publicação
Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle
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Orientador(es)
Resumo(s)
The transcription and expression patterns of Notch pathway components (Notch 1–3, Delta1 and 4, Jagged1) and effectors
(Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key moments of post-natal
development, and along the adult spermatogenic cycle. Notch pathway components and effectors are transcribed in the
testis and expressed in germ, Sertoli and Leydig cells, and each Notch component shows a specific cell-type and timewindow
expression pattern. This expression at key testis developmental events prompt for a role of Notch signaling in prepubertal
spermatogonia quiescence, onset of spermatogenesis, and regulation of the spermatogenic cycle.
Descrição
Articles in International Journals
Palavras-chave
Germ cells Immunostaining Notch signaling Sertoli cells Spermatids Spermatocytes Spermatogenesis Spermatogonia
Contexto Educativo
Citação
Murta, D., Batista, M., Silva, E., Trindade, A., Henrique, D., Duarte, A. et al. (2013). Dynamics of Notch Pathway Expression during Mouse Testis Post-Natal Development and along the Spermatogenic Cycle. PLoS ONE 8(8): e72767. doi:10.1371/journal.pone.0072767
Editora
Jean-Marc A. Lobaccaro, Clermont Université , France