Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle

Murta, Daniel; Batista, Marta; Silva, Elisabete; Trindade, Alexandre; Henrique, Domingos; Duarte, António; Lopes da Costa, Luís

http://hdl.handle.net/10400.5/7310

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Abstract(s)

The transcription and expression patterns of Notch pathway components (Notch 1–3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key moments of post-natal development, and along the adult spermatogenic cycle. Notch pathway components and effectors are transcribed in the testis and expressed in germ, Sertoli and Leydig cells, and each Notch component shows a specific cell-type and timewindow expression pattern. This expression at key testis developmental events prompt for a role of Notch signaling in prepubertal spermatogonia quiescence, onset of spermatogenesis, and regulation of the spermatogenic cycle.

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Articles in International Journals

Keywords

Germ cells Immunostaining Notch signaling Sertoli cells Spermatids Spermatocytes Spermatogenesis Spermatogonia

URI

http://hdl.handle.net/10400.5/7310

Citation

Murta, D., Batista, M., Silva, E., Trindade, A., Henrique, D., Duarte, A. et al. (2013). Dynamics of Notch Pathway Expression during Mouse Testis Post-Natal Development and along the Spermatogenic Cycle. PLoS ONE 8(8): e72767. doi:10.1371/journal.pone.0072767