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Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle

2013-08-28Journal article Open access
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dc.contributor.authorMurta, Daniel
dc.contributor.authorBatista, Marta
dc.contributor.authorSilva, Elisabete
dc.contributor.authorTrindade, Alexandre
dc.contributor.authorHenrique, Domingos
dc.contributor.authorDuarte, António
dc.contributor.authorLopes da Costa, Luís
dc.date.accessioned2014-10-14T11:18:52Z
dc.date.available2014-10-14T11:18:52Z
dc.date.issued2013-08-28
dc.descriptionArticles in International Journalspor
dc.description.abstractThe transcription and expression patterns of Notch pathway components (Notch 1–3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key moments of post-natal development, and along the adult spermatogenic cycle. Notch pathway components and effectors are transcribed in the testis and expressed in germ, Sertoli and Leydig cells, and each Notch component shows a specific cell-type and timewindow expression pattern. This expression at key testis developmental events prompt for a role of Notch signaling in prepubertal spermatogonia quiescence, onset of spermatogenesis, and regulation of the spermatogenic cycle.por
dc.identifier.citationMurta, D., Batista, M., Silva, E., Trindade, A., Henrique, D., Duarte, A. et al. (2013). Dynamics of Notch Pathway Expression during Mouse Testis Post-Natal Development and along the Spermatogenic Cycle. PLoS ONE 8(8): e72767. doi:10.1371/journal.pone.0072767por
dc.identifier.doi10.1371/journal.pone.0072767
dc.identifier.issn1932-6203 (online)
dc.identifier.urihttp://hdl.handle.net/10400.5/7310
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherJean-Marc A. Lobaccaro, Clermont Université , Francepor
dc.relationThe Notch-Delta signalling pathway in the reproductive function of the mouse and cow
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0072767por
dc.subjectGerm cellspor
dc.subjectImmunostainingpor
dc.subjectNotch signalingpor
dc.subjectSertoli cellspor
dc.subjectSpermatidspor
dc.subjectSpermatocytespor
dc.subjectSpermatogenesispor
dc.subjectSpermatogoniapor
dc.titleDynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cyclepor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe Notch-Delta signalling pathway in the reproductive function of the mouse and cow
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCVT%2F105022%2F2008/PT
oaire.citation.endPage12por
oaire.citation.startPage1por
oaire.citation.titlePLoS ONEpor
oaire.citation.volume8(Issue 8):e72767por
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isProjectOfPublication202eb379-5a61-4a7e-a753-16f5c2c67744
relation.isProjectOfPublication.latestForDiscovery202eb379-5a61-4a7e-a753-16f5c2c67744

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