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Advisor(s)
Abstract(s)
In adults, physiological angiogenesis is a rare event, with few exceptions as the vasculogenesis needed for tissue growth and
function in female reproductive organs. Particularly in the corpus luteum(CL), regulation of angiogenic process seems to be tightly
controlled by opposite actions resultant fromthe balance between pro- and antiangiogenic factors. It is the extremely rapid sequence
of events that determines the dramatic changes on vascular and nonvascular structures, qualifying the CL as a great model for
angiogenesis studies. Using the mare CL as a model, reports on locally produced cytokines, such as tumor necrosis factor α (TNF),
interferon gamma (IFNG), or Fas ligand (FASL), pointed out their role on angiogenic activity modulation throughout the luteal
phase.Thus, the main purpose of this review is to highlight the interaction between immune, endothelial, and luteal steroidogenic
cells, regarding vascular dynamics/changes during establishment and regression of the equine CL.
Description
Articles in International Journals
Keywords
Cytokine Corpus luteum Angiogenesis
Pedagogical Context
Citation
Galvão, A.M., Ferreira-Dias, G.M., & Skarzynski, D.J. (2013). Cytokines and angiogenesis in the corpus luteum. Mediators of Inflammation 2013(Article ID 420186), 1-11. doi: 10.1155/2013/420186
Publisher
Hindawi Publishing Corporation. Academic Editor Jeffrey H. Ruth