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Anticancer properties of astaxanthin
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Abstract(s)
O cancro é uma das causas de morte mais prevalentes em países desenvolvidos, colocando um peso significativo nos seus sistemas de saúde e tendo um grande impacto na qualidade de vida da população. As estratégias de terapêutica atuais incluem ressecção cirúrgica, quimioterapia e radioterapia, entre outras. Embora todas estas opções melhorem a taxa de sobrevida do doente, frequentemente apresentam desvantagens, tais como efeitos secundários que afetem a capacidade de o doente realizar as suas atividades de vida diárias, toxicidade, ou falências secundárias.
A astaxantina (ASTX) é um carotenoide xantófilo frequentemente encontrado em algas e animais aquáticos, frequentemente usado como corante em peixes e comida para animais. Vários estudos demonstraram que, além dos seus efeitos benéficos ao nível da saúde da pele, ocular, cardiovascular e neurológica, demonstrou resultados promissores no tratamento do cancro. A ASTX apresenta vários mecanismos anticancerígenos, incluindo efeito anti-proliferativo, anti-apoptótico e anti-invasivo. Doentes suplementados com ASTX não reportaram efeitos secundários, o que a torna ainda mais apelativa como terapêutica para o cancro. Esta dissertação tem como objetivo fazer uma revisão dos potenciais usos da ASTX no combate ao cancro e ilustrar os seus principais mecanismos de ação.
Cancer is one of the leading causes of death in developed countries, placing a significant strain on a country’s health system and greatly impacting the population’s quality of life. Current treatment strategies include surgical resection, chemotherapy and radiation therapy, among other. While all of them increase patient survival rates, they often have their own drawbacks, such as severe side effects that impact the patient’s ability to perform their daily activities, toxicity, or development of therapy resistance. Astaxanthin (ASTX) is a xanthophyll carotenoid widely found in algae and aquatic animals that is frequently used as food colorant in fish and animal feed. Several studies have shown that ASTX is a potent antioxidant and anti-inflammatory, which piqued interest as a therapeutic agent for several diseases, including cancer. In addition to the benefits in the skin and eye health and a protective effect against cardiovascular and neurological diseases, ASTX shows promising results as an anticancer agent. It displays several anticancer mechanisms of action, including anti-proliferation, anti-apoptosis, and anti-invasion. Patients taking ASTX supplementation also did not report side effects, further increasing its value as an anticancer agent. The aim of this study is to review the potential uses of ASTX in cancer, as well as illustrate its main mechanisms of action.
Cancer is one of the leading causes of death in developed countries, placing a significant strain on a country’s health system and greatly impacting the population’s quality of life. Current treatment strategies include surgical resection, chemotherapy and radiation therapy, among other. While all of them increase patient survival rates, they often have their own drawbacks, such as severe side effects that impact the patient’s ability to perform their daily activities, toxicity, or development of therapy resistance. Astaxanthin (ASTX) is a xanthophyll carotenoid widely found in algae and aquatic animals that is frequently used as food colorant in fish and animal feed. Several studies have shown that ASTX is a potent antioxidant and anti-inflammatory, which piqued interest as a therapeutic agent for several diseases, including cancer. In addition to the benefits in the skin and eye health and a protective effect against cardiovascular and neurological diseases, ASTX shows promising results as an anticancer agent. It displays several anticancer mechanisms of action, including anti-proliferation, anti-apoptosis, and anti-invasion. Patients taking ASTX supplementation also did not report side effects, further increasing its value as an anticancer agent. The aim of this study is to review the potential uses of ASTX in cancer, as well as illustrate its main mechanisms of action.
Description
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2024, Universidade de Lisboa, Faculdade de Farmácia .
Keywords
Cancer risk factors Cancer therapy Astaxanthin Carotenoids Antioxidant Mestrado Integrado - 2024