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Ácido beta-hidroxibutírico : avaliação da concentração sérica em gatos e relação com as apresentações clínicas, diagnósticos e taxa de sobrevivência
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Resumo(s)
Em situações de balanço energético negativo, a disponibilidade reduzida de glicose estimula a oxidação de ácidos gordos livres no fígado. A saturação do ciclo do ácido cítrico, mobiliza acetil-coenzima A para a cetogénese, no sentido de produzir energia como via alternativa à glicólise. Este processo origina um substrato energético alternativo, os corpos cetónicos. O ácido beta-hidroxibutírico é o corpo cetónico mais abundante no organismo felino, encontrando-se moderadamente aumentado em períodos de jejum. A concentração aumentada deste composto tem consequências graves no organismo. A diabetes mellitus quando não controlada, é a doença com maior capacidade de elevar a concentração sérica de ácido beta-hidroxibutírico. No entanto, outras doenças podem alterar o metabolismo para um estado catabólico. O presente estudo teve como objetivos caracterizar a apresentação clínica e os resultados das análises laboratoriais de 70 felinos hospitalizados, que apresentavam concentrações séricas de ácido beta-hidroxibutírico aumentadas e normais, bem como avaliar a existência de uma relação entre a elevação deste corpo cetónico nas diferentes doenças estudadas e também a taxa de sobrevivência. Os resultados obtidos revelaram que diversas doenças aumentam a concentração sérica de ácido beta-hidroxibutírico, nomeadamente obstruções intestinais (100%, 2/2), Lipidose Hepática Felina (LHF) (60%, 3/5), hipertiroidismo (50%, 3/6), obstruções urinárias (44%, 4/9), outras hepatopatias (42%, 3/7), pancreatite (28%, 4/14), cardiopatias (28%, 2/7), DRC (23%, 6/26) e neoplasias (17%, 1/6). Em animais doentes não diabéticos, a [BHB]s foi significativamente superior comparativamente aos animais saudáveis (p=0,004). No entanto, não foi encontrada uma relação significativa entre a concentração de ácido beta-hidroxibutírico e outros parâmetros bioquímicos ou sinais clínicos. A taxa de sobrevivência dos animais doentes não diabéticos sugere ser mais elevada quando a concentração de ácido beta-hidroxibutírico está aumentada, contudo, são necessários mais estudos para comprovar a significância desta relação
ABSTRACT - Beta-hydroxybutyric acid: evaluation of serum concentration in cats and relationship with clinical presentations, diagnoses and survival rate - In situations of negative energy balance, the reduced availability of glucose stimulates the oxidation of free fatty acids in the liver. Saturation of the citric acid cycle mobilizes acetyl coenzyme A for ketogenesis, as an alternative pathway to glycolysis, in order to produce energy. This process originates an alternative energy substrate, ketone bodies. Beta hydroxybutyric acid is the most abundant ketone body in the feline organism, increased in moderate quantities during fasting periods. An increased concentration of this compound has severe consequences on the organism. Diabetes mellitus, when uncontrolled, has the highest capacity to elevate the serum concentration of beta-hydroxybutyric acid. However, other diseases can shift the metabolism to a catabolic state. The present study aimed to characterize the clinical presentation and laboratory analyses of 70 hospitalized felines, with increased and normal serum concentrations of beta hydroxybutyric acid, as well as to understand if there is a relationship between the elevation of this ketone body in different diseases and to evaluate the survival rate. The obtained results revealed that various diseases increase the serum concentration of beta-hydroxybutyric acid, including intestinal obstructions (100%, 2/2), hepatic lipidosis (HL) (60%, 3/5), hyperthyroidism (50%, 3/6), urinary obstruction (44%, 4/9), other hepatopathies (42%, 3/7), pancreatitis (28%, 4/14), cardiopathy (28%, 2/7), chronic kidney disease (CKD) (23%, 6/26), and neoplasia (17%, 1/6). In non-diabetic sick animals, [BHB]s were significantly higher compared to healthy animals (p=0.004). However, no significant relationship was found between the concentration of beta-hydroxybutyric acid and other biochemical parameters or clinical signs. The survival rate of non-diabetic sick animals suggests to be higher when the concentration of beta hydroxybutyric acid is increased, however, further studies are required to establish the significance of this finding
ABSTRACT - Beta-hydroxybutyric acid: evaluation of serum concentration in cats and relationship with clinical presentations, diagnoses and survival rate - In situations of negative energy balance, the reduced availability of glucose stimulates the oxidation of free fatty acids in the liver. Saturation of the citric acid cycle mobilizes acetyl coenzyme A for ketogenesis, as an alternative pathway to glycolysis, in order to produce energy. This process originates an alternative energy substrate, ketone bodies. Beta hydroxybutyric acid is the most abundant ketone body in the feline organism, increased in moderate quantities during fasting periods. An increased concentration of this compound has severe consequences on the organism. Diabetes mellitus, when uncontrolled, has the highest capacity to elevate the serum concentration of beta-hydroxybutyric acid. However, other diseases can shift the metabolism to a catabolic state. The present study aimed to characterize the clinical presentation and laboratory analyses of 70 hospitalized felines, with increased and normal serum concentrations of beta hydroxybutyric acid, as well as to understand if there is a relationship between the elevation of this ketone body in different diseases and to evaluate the survival rate. The obtained results revealed that various diseases increase the serum concentration of beta-hydroxybutyric acid, including intestinal obstructions (100%, 2/2), hepatic lipidosis (HL) (60%, 3/5), hyperthyroidism (50%, 3/6), urinary obstruction (44%, 4/9), other hepatopathies (42%, 3/7), pancreatitis (28%, 4/14), cardiopathy (28%, 2/7), chronic kidney disease (CKD) (23%, 6/26), and neoplasia (17%, 1/6). In non-diabetic sick animals, [BHB]s were significantly higher compared to healthy animals (p=0.004). However, no significant relationship was found between the concentration of beta-hydroxybutyric acid and other biochemical parameters or clinical signs. The survival rate of non-diabetic sick animals suggests to be higher when the concentration of beta hydroxybutyric acid is increased, however, further studies are required to establish the significance of this finding
Descrição
Dissertação de Mestrado Integrado em Medicina Veterinária, área científica de Clínica
Palavras-chave
Corpos cetónicos Ácido beta-hidroxibutírico Cetose Gato Diabetes mellitus Ketone bodies Beta-hydroxybutyric acid ketosis Cat Diabetes mellitus
Contexto Educativo
Citação
Francisco MISG. 2024. Ácido beta-hidroxibutírico : avaliação da concentração sérica em gatos e relação com as apresentações clínicas, diagnósticos e taxa de sobrevivência [dissertação de mestrado]. Lisboa: FMV-Universidade de Lisboa
Editora
Universidade de Lisboa, Faculdade de Medicina Veterinária