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Comparação entre as vacinas Letifend® e CaniLeish® relativamente aos seus efeitos secundários em cães domésticos : um estudo retrospetivo
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Resumo(s)
A leishmaniose canina é provocada pelo parasita Leishmania infantum, sendo que, a doença tem efeitos generalizados no organismo, uma vez que afeta células do sistema fagocitário mononuclear, como os macrófagos. Atualmente, um dos métodos de controlo e prevenção desta doença envolve o uso de vacinas nos cães.
O objetivo principal deste estudo retrospetivo foi avaliar a incidência e o tipo de efeitos secundários desenvolvidos pelos cães após o uso de duas vacinas, a CaniLeish® e a Letifend® e posteriormente comparar as duas vacinas em termos da sua segurança.
Foram colhidos dados de 157 cães (73 inoculados com CaniLeish® e 84 com Letifend®). Dos animais vacinados com CaniLeish®, 15 desenvolveram efeitos adversos, sendo que, a incidência destes efeitos não aparentou estar relacionado com a idade ou com o sexo do animal. Contudo, parece ter havido uma relação com o peso dos cães, uma vez que, 12 dos animais afetados tinham um peso inferior a 15 Kg. Consequentemente, as raças de cães que apresentavam estes efeitos eram na maioria de pequeno porte, como o Yorkshire Terrier. Pelo contrário os animais vacinados com Letifend® não desenvolveram qualquer efeito adverso, pelo que, com base na amostra estudada, concluiu-se que esta é uma vacina mais segura comparativamente com a CaniLeish® no que respeita ao aparecimento de reações secundárias.
ABSTRACT - COMPARISON BETWEEN THE VACCINES CANILEISH® AND LETIFEND® IN RELATION TO THEIR SECONDARY EFFECTS IN DOMESTIC DOGS: A RETROSPECTIVE STUDY - Canine leishmaniasis is caused by the parasite Leishmania infantum, and the disease has widespread effects on the body, as it affects cells of the mononuclear phagocytic system, such as macrophages. Currently, one of the methods of control and prevention of this disease involves the use of vaccines in dogs. The main objective of this retrospective study was to assess the incidence and type of secondary effects developed in dogs after the use of two vaccines, CaniLeish® and Letifend®, and then compare the two vaccines in terms of their safety. Data was collected from 157 dogs (73 inoculated with CaniLeish® and 84 with Letifend®). Of the animals vaccinated with CaniLeish®, 15 developed adverse effects but the incidence of these effects did not appear to be related to the age or sex of the animal. However, there seems to have been a relationship with the weight of the dogs since 12 of the affected animals weighed less than 15 kg. Consequently, the breeds of dogs that had these effects were mostly small, such as the Yorkshire Terrier. On the contrary, the animals vaccinated with Letifend® did not develop any adverse effects, based on the studied sample, so it was concluded that this is a safer vaccine compared to CaniLeish® in what concerns secondary reactions.
ABSTRACT - COMPARISON BETWEEN THE VACCINES CANILEISH® AND LETIFEND® IN RELATION TO THEIR SECONDARY EFFECTS IN DOMESTIC DOGS: A RETROSPECTIVE STUDY - Canine leishmaniasis is caused by the parasite Leishmania infantum, and the disease has widespread effects on the body, as it affects cells of the mononuclear phagocytic system, such as macrophages. Currently, one of the methods of control and prevention of this disease involves the use of vaccines in dogs. The main objective of this retrospective study was to assess the incidence and type of secondary effects developed in dogs after the use of two vaccines, CaniLeish® and Letifend®, and then compare the two vaccines in terms of their safety. Data was collected from 157 dogs (73 inoculated with CaniLeish® and 84 with Letifend®). Of the animals vaccinated with CaniLeish®, 15 developed adverse effects but the incidence of these effects did not appear to be related to the age or sex of the animal. However, there seems to have been a relationship with the weight of the dogs since 12 of the affected animals weighed less than 15 kg. Consequently, the breeds of dogs that had these effects were mostly small, such as the Yorkshire Terrier. On the contrary, the animals vaccinated with Letifend® did not develop any adverse effects, based on the studied sample, so it was concluded that this is a safer vaccine compared to CaniLeish® in what concerns secondary reactions.
Descrição
Dissertação de Mestrado Integrado em Medicina Veterinária
Palavras-chave
Leishmania infantum leishmaniose canina vacinas CaniLeish® Letifend® efeitos secundários canine leishmaniasis vaccines secondary effects
Contexto Educativo
Citação
Fonseca BN 2020. Comparação entre as vacinas Letifend® e CaniLeish® relativamente aos seus efeitos secundários em cães domésticos: um estudo retrospetivo [dissertação de mestrado]. Lisboa: FMV-Universidade de Lisboa.
Editora
Universidade de Lisboa, Faculdade de Medicina Veterinária