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Screening do perfil de resistência dos isolados de Aspergillus secção Fumigati
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Resumo(s)
Aspergillus section Fumigati is the section of the Aspergillus genus most associated with the development of respiratory diseases and is the primary etiological agent of invasive aspergillosis, a pathology with high mortality rate among immunocompromised individuals. The increasing use of antifungals, both in clinical and environmental settings, has contributed to the rise in resistance of Aspergillus section Fumigati, especially to azole antifungals, thus compromising the treatment of invasive fungal infections. These fungi are present in a variety of environmental conditions, including soil and decaying organic matter, and can be found in occupational settings such as waste management and sorting industries. Therefore, workers exposed to Aspergillus section Fumigati have an additional risk of developing respiratory problems and fungal infections. This dissertation aims to characterize the antifungal resistance profile of Aspergillus section Fumigati isolates, in the waste management and sorting industry, thus enabling an understanding of occupational exposure to these fungi in this setting. Aspergillussection Fumigati isolates from a waste management and sorting industry in Canada and from waste collection trucks belonging to a waste collection industry in Lisbon were analyzed. The resistance profile was assessed through epsilometer test for different antifungal drugs: itraconazole, voriconazole, posaconazole and amphotericin B. A total of 10 isolates were analyzed, of which 50.00% demonstrated resistance to one of the antifungals tested, specifically posaconazole (30.00%) and itraconazole (20.00%), according with the breakpoints described by the EUCAST 2020 guidelines. The results confirm the presence of Aspergillus section Fumigati isolates with azole resistance in both waste management and sorting industries evaluated, highlighting occupational exposure to these fungi in this professional environment and underscoring the significance of antifungal resistance development and the urgent need for appropriate control measures.
Descrição
Tese de Mestrado, Biologia Humana e Ambiente, 2025, Universidade de Lisboa, Faculdade de Ciências
Palavras-chave
Aspergillussection Fumigati Occupational exposure Waste Industry Antifungal resistance