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Differential inhibition of gelatinase activity in human colon adenocarcinoma cells by Aloe vera and Aloe arborescens extracts

2020Journal article Open access
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dc.contributor.authorLima, Ana
dc.contributor.authorBatista-Santos, Paula
dc.contributor.authorVeríssimo, Eduarda
dc.contributor.authorRebelo, Patrícia
dc.contributor.authorFerreira, Ricardo Boavida
dc.date.accessioned2021-01-05T15:16:10Z
dc.date.available2021-01-05T15:16:10Z
dc.date.issued2020
dc.descriptionResearch Articlept_PT
dc.description.abstractBackground: Aloe’s reported bioactivities (anticancer, anti-inflammatory and wound healing) suggest they might inhibit a subgroup of matrix metalloproteinases (MMPs) called gelatinases (MMP-2 and MMP-9). The goal of the present study was to compare the MMP inhibitory potential of two Aloe species, A. vera and A. arborescens. Methods: Different types of extraction were tested and specific bioactive compounds were quantified. Cancer cell invasion inhibitory activities were measured in vitro using the wound healing assay in human colon cancer cells (HT29). Effects on gelatinase activities were further assessed by dye-quenched gelatin and gelatin zymography. Results: Different types of extraction yielded significantly different levels of bioactivities and of bioactive compounds, which might be due to a greater amount of extractable bioactive compounds such as anthraquinones. Both A. arborescens and A. vera have potential as inhibitory agents in cancer cell proliferation via MMP-9 and MMP-2 enzymatic activity inhibition, being able to reduce colon cancer cell proliferation and migration but A. arborescens showed to be a more effective inhibitor of cancer cell migration than A. vera. Conclusion: This work opens novel perspectives on the mode of action of Aloe species in cancer cell migration and may provide clues as to why there are so many conflicting results on Aloe’s activitiespt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLima et al. BMC Complementary Medicine and Therapies (2020) 20:379pt_PT
dc.identifier.doihttps://doi.org/10.1186/s12906-020-03134-9pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/20743
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAloept_PT
dc.subjectcolon cancerpt_PT
dc.subjectinflammationpt_PT
dc.subjectgelatinasespt_PT
dc.subjectextractionpt_PT
dc.titleDifferential inhibition of gelatinase activity in human colon adenocarcinoma cells by Aloe vera and Aloe arborescens extractspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleBMC Complementary Medicine and Therapiespt_PT
person.familyNameBento Batista dos Santos
person.familyNameFerreira
person.givenNamePaula Cristina
person.givenNameRicardo Boavida
person.identifierX-9778-2018
person.identifier86030
person.identifier.ciencia-idED1E-E33A-0B5A
person.identifier.ciencia-id371D-28A0-4027
person.identifier.orcid0000-0002-5442-1092
person.identifier.orcid0000-0002-5027-7564
person.identifier.scopus-author-id36087137800
person.identifier.scopus-author-id8285312700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8b9c9a04-7672-4b02-9eec-de91cd2b79c7
relation.isAuthorOfPublication0f32c437-6c87-47d7-998b-c97c4695806a
relation.isAuthorOfPublication.latestForDiscovery0f32c437-6c87-47d7-998b-c97c4695806a

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