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Advisor(s)
Abstract(s)
Background: Aloe’s reported bioactivities (anticancer, anti-inflammatory and wound healing) suggest they might
inhibit a subgroup of matrix metalloproteinases (MMPs) called gelatinases (MMP-2 and MMP-9). The goal of the
present study was to compare the MMP inhibitory potential of two Aloe species, A. vera and A. arborescens.
Methods: Different types of extraction were tested and specific bioactive compounds were quantified. Cancer cell
invasion inhibitory activities were measured in vitro using the wound healing assay in human colon cancer cells
(HT29). Effects on gelatinase activities were further assessed by dye-quenched gelatin and gelatin zymography.
Results: Different types of extraction yielded significantly different levels of bioactivities and of bioactive
compounds, which might be due to a greater amount of extractable bioactive compounds such as anthraquinones.
Both A. arborescens and A. vera have potential as inhibitory agents in cancer cell proliferation via MMP-9 and MMP-2
enzymatic activity inhibition, being able to reduce colon cancer cell proliferation and migration but A. arborescens
showed to be a more effective inhibitor of cancer cell migration than A. vera.
Conclusion: This work opens novel perspectives on the mode of action of Aloe species in cancer cell migration
and may provide clues as to why there are so many conflicting results on Aloe’s activities
Description
Research Article
Keywords
Aloe colon cancer inflammation gelatinases extraction
Pedagogical Context
Citation
Lima et al. BMC Complementary Medicine and Therapies (2020) 20:379
Publisher
BMC