Publicação
Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors
| dc.contributor.author | Clemente, A | |
| dc.contributor.author | Domingos, A | |
| dc.contributor.author | Grancho, AP | |
| dc.contributor.author | Iley, J | |
| dc.contributor.author | Moreira, R | |
| dc.contributor.author | Neres, J | |
| dc.contributor.author | Palma, N | |
| dc.contributor.author | Santana, AB | |
| dc.contributor.author | Valente, E | |
| dc.date.accessioned | 2015-12-30T10:17:38Z | |
| dc.date.available | 2015-12-30T10:17:38Z | |
| dc.date.issued | 2001 | |
| dc.description.abstract | A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones. 3, with different substituent patterns at the beta -lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme, (C) 2001 Elsevier Science Ltd. All rights reserved. | |
| dc.format | application/pdf | |
| dc.identifier.citation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - Vol. 11, n. 8 (APR 23 2001), p. 1065-1068 | |
| dc.identifier.issn | 0960-894X | |
| dc.identifier.uri | http://hdl.handle.net/10451/21168 | |
| dc.language.iso | eng | |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | |
| dc.subject | Chemistry, Medicinal | |
| dc.subject | Chemistry, Organic | |
| dc.title | Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors | |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1068 | por |
| oaire.citation.startPage | 1065 | por |
| oaire.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | por |
| oaire.citation.volume | Vol. 11 | por |
| rcaap.rights | restrictedAccess | |
| rcaap.type | article |