Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

Clemente, A; Domingos, A; Grancho, AP; Iley, J; Moreira, R; Neres, J; Palma, N; Santana, AB; Valente, E

http://hdl.handle.net/10451/21168

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Resumo(s)

A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones. 3, with different substituent patterns at the beta -lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme, (C) 2001 Elsevier Science Ltd. All rights reserved.

Palavras-chave

Chemistry, Medicinal Chemistry, Organic

URI

http://hdl.handle.net/10451/21168

Citação

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - Vol. 11, n. 8 (APR 23 2001), p. 1065-1068

Editora

PERGAMON-ELSEVIER SCIENCE LTD

Coleções

FF - Produção Científica 2000-2009

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