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Características clínico-patológicas e implicação prognóstica do adenocarcinoma mucinoso no carcinoma colo-rectal
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Introdução: O adenocarcinoma mucinoso colo-rectal é conhecido e tem sido estudado desde há vários anos. No entanto, a importância prognóstica deste subtipo histológico permanece controversa. Foram estudadas as características clínicopatológicas e implicação prognóstica destes tumores.
Metodologia: Este estudo incluiu 206 doentes operados por carcinoma colo-rectal no ano de 2012. Os doentes foram agrupados em três grupos de acordo com o conteúdo do tumor em mucina: >50%, adenocarcinoma mucinoso (MAC); <50%, adenocarcinoma com componente mucinoso (AIM); e adenocarcinoma não mucinoso (NMA).
Resultados: Dos 206 doentes, 13 (6.3%) tinham MAC, 36 (17.5%) tinham AIM e os restantes 157 (76.2%) apresentavam NMA. O adenocarcinoma mucinoso e AIM apresentaram maior grau de invasão tumoral (T3 e T4), e o primeiro apresentou também maior frequência de metastização cerebral.
Conclusão: O adenocarcinoma mucinoso apresenta características clínico-patológicas distintas comparado com AIM e NMA. A histologia mucinosa não apresentou correlação significativa com o prognóstico, quando comparada com NMA.
Background: Colorectal mucinous adenocarcinoma has been known and studied for several years. However, the prognostic significance of this histologic subtype remains controversial. Clinicopathological features and prognostic implication of these tumours were studied. Methods: This study included 206 patients who underwent surgery for colorectal carcinoma in 2012. Patients were grouped according to mucinous content: >50%, mucinous adenocarcinoma (MAC); <50%, adenocarcinoma with intermediate mucinous component (AIM); and without any mucinous component, non-MAC (NMA). Results: Among 206 patients, 13 (6.3%) had MAC, 36 (17.5%) had AIM and the remaining 157 (76.2%) had NMA. Mucinous adenocarcinoma and AIM presented with greater tumoral invasion (T3 and T4) and the first had also higher frequency of cerebral metastization. Conclusion: Mucinous adenocarcinoma has distinct clinicopathological features compared with AIM and NMA. Mucinous histology had no significant correlation with prognosis compared with NMA.
Background: Colorectal mucinous adenocarcinoma has been known and studied for several years. However, the prognostic significance of this histologic subtype remains controversial. Clinicopathological features and prognostic implication of these tumours were studied. Methods: This study included 206 patients who underwent surgery for colorectal carcinoma in 2012. Patients were grouped according to mucinous content: >50%, mucinous adenocarcinoma (MAC); <50%, adenocarcinoma with intermediate mucinous component (AIM); and without any mucinous component, non-MAC (NMA). Results: Among 206 patients, 13 (6.3%) had MAC, 36 (17.5%) had AIM and the remaining 157 (76.2%) had NMA. Mucinous adenocarcinoma and AIM presented with greater tumoral invasion (T3 and T4) and the first had also higher frequency of cerebral metastization. Conclusion: Mucinous adenocarcinoma has distinct clinicopathological features compared with AIM and NMA. Mucinous histology had no significant correlation with prognosis compared with NMA.
Descrição
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2015
Palavras-chave
Adenocarcinoma mucinoso Componente mucinoso Carcinoma colorectal Clínico-patologia Prognóstico