Browsing by Author "Cravo, Pedro"
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- Antiplasmodial Activity of Lignans and Extracts from Pycnanthus angolensisPublication . Abrantes, Marta; Mill-Homens, Tania; Duarte, Noelia; Lopes, Dinora; Cravo, Pedro; Madureira, Maria do Ceu; Ferreira, Maria-Jose U.The dichloromethane, methanol and aqueous ethanol extracts of the stem bark of Pycnanthus angolensis were evaluated for their in vitro activity against the 3D7 Plasmodium falciparum strain. The CH2Cl2 extract was the most active showing an IC50 = 1.6 mu g/mL. From this extract, a new dibenzylbutane lignan, threo-4,4'-dihydroxy-3-methoxylignan (1) named pycnantolol, together with the known lignans (-)-dihydroguaiaretic acid (2), heliobuphthalmin (3), talaumidin (4), hinokinin (5), the labdane-type diterpene ozic acid (6), and the steroids stigmast-4-en-6 beta-ol-3-one (7), beta-sitosterol (8) and stigmasterol (9) were isolated. Their structures were established on the basis of physical and spectroscopic methods, including 2 D NMR experiments (COSY, HMQC, HMBC and NOESY). The antimalarial activity of compounds 1 - 7 was evaluated against 3D7 and Dd2 P. falciparum strains. Despite the significant activity displayed by the crude CH2Cl2 extract, the isolated compounds showed weaker antiplasmodial activity. The lowest IC50 value was obtained for talaumidin (4) (IC50 = 20.7 mu g/mL against the Dd2-chloroquine resistant P. falciparum strain).. - Science and Technology Foundation (FCT), Portugal. - The authors thank Prof. Jorge Paiva (Instituto Botanico, University of Coimbra) for identification of the plant. This work was supported by the Science and Technology Foundation (FCT), Portugal.
- Evaluation of the Polyphenolic Composition and Bioactivities of Three Native Cabo Verde Medicinal PlantsPublication . Essoh, Anyse P.; Liberal, Ângela; Fernandes, Ângela; Dias, Maria Inês; Pereira, Carla; Mandim, Filipa; Moldão, Margarida; Cravo, Pedro; Duarte, Maria Paula; Moura, Mónica; Romeiras, Maria M.; Barros, LillianThe use of medicinal plants in a variety of health conditions remains essential for the discovery of new treatments. The present study aimed to investigate the bioactive properties of three native plants from Cabo Verde Islands, namely Artemisia gorgonum Webb, Sideroxylon marginatum (Decne. ex Webb) Cout., and Tamarix senegalensis DC., contributing to the characterization of lessknown medicinal plants and their potential benefits for human health. Known compounds, such as kaempferol, quercetin, caffeyolquinic, and apigenin derivatives, among others, were detected in the plant species under study. Overall, all species demonstrated good antioxidant capacity, especially the ethanolic extracts of A. gorgonum (EC50 = 0.149 mg/mL) in TBARS assay. Moreover, the ethanolic extracts of the studied plants showed cytotoxic properties against tumor cells, and again the A. gorgonum extract proved to be the most effective in inhibiting tumor growth, mainly in the CaCO2 (GI50 = 17.3 g/mL) and AGS (GI50 = 18.2 g/mL) cell lines. Only the ethanolic extracts of T. senegalensis and S. marginatum demonstrated anti-inflammatory activity, albeit weak (EC50 = 35 and 43 g/mL, respectively). The present study contributed to increased knowledge about the bioactive properties of these plants commonly used in traditional medicine, some of which was discussed for the first time, opening new perspectives for their use in a wider range of health conditions, especially in African countries, where access to modern health care is more limited
- Evaluation of the Polyphenolic Composition and Bioactivities of Three Native Cabo Verde Medicinal PlantsPublication . P. Essoh, Anyse; Liberal, Ângela; Fernandes, Ângela; Dias, Maria Inês; Pereira, Carla; Mandim, Filipa; Moldão, Margarida; Cravo, Pedro; Duarte, Maria Paula; Moura, Mónica; Romeiras, Maria M.; Barros, LillianThe use of medicinal plants in a variety of health conditions remains essential for the discovery of new treatments. The present study aimed to investigate the bioactive properties of three native plants from Cabo Verde Islands, namely Artemisia gorgonum Webb, Sideroxylon marginatum (Decne. ex Webb) Cout., and Tamarix senegalensis DC., contributing to the characterization of less-known medicinal plants and their potential benefits for human health. Known compounds, such as kaempferol, quercetin, caffeyolquinic, and apigenin derivatives, among others, were detected in the plant species under study. Overall, all species demonstrated good antioxidant capacity, especially the ethanolic extracts of A. gorgonum (EC50 = 0.149 mg/mL) in TBARS assay. Moreover, the ethanolic extracts of the studied plants showed cytotoxic properties against tumor cells, and again the A. gorgonum extract proved to be the most effective in inhibiting tumor growth, mainly in the CaCO2 (GI50 = 17.3 μg/mL) and AGS (GI50 = 18.2 μg/mL) cell lines. Only the ethanolic extracts of T. senegalensis and S. marginatum demonstrated anti-inflammatory activity, albeit weak (EC50 = 35 and 43 μg/mL, respectively). The present study contributed to increased knowledge about the bioactive properties of these plants commonly used in traditional medicine, some of which was discussed for the first time, opening new perspectives for their use in a wider range of health conditions, especially in African countries, where access to modern health care is more limited.