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Metallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)?

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Resumo(s)

Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) is a new entity in which exposure to an adjuvant triggers an aberrant autoimmune response. Metallosis is a rare condition characterized by the deposition and build-up of metal debris in the soft tissues of the body associated with metal-on-metal (MOM) prosthetic devices. It can present with local/systemic symptoms and signs due to a chronic inflammatory host response. The authors present the case of a 51-year-old woman with a 6-month history of systemic complaints due to intoxication with metal ions from hip metallosis. This case highlights the importance of follow-up and continuous monitoring of patients with a hip prosthesis. As this is a rare condition, a patient presenting with unspecific symptoms such as ASIA syndrome induced by metallosis requires a high level of clinical suspicion as the removal of the adjuvant can resolve the condition. Learning points: Asia syndrome is a new entity in which exposure to an adjuvant triggers an aberrant autoimmune response.Metallosis is an uncommon condition with local and systemic presentation.A high level of suspicion and close monitoring is needed in patients with vague systemic complaints.

Descrição

European Journal of Case Reports in Internal Medicine © EFIM 2019

Palavras-chave

ASIA syndrome Metallosis

Contexto Educativo

Citação

Eur J Case Rep Intern Med. 2019 Feb 25;6(3):001034

Projetos de investigação

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Fascículo

Editora

SMC media Srl

Licença CC

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