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Advisor(s)
Abstract(s)
A Doença de Alzheimer é uma doença neurodegenerativa muito comum, sendo a causa de demência mais presente no Mundo. A sua prevalência está a aumentar ao longo dos anos e, até à data, não é possível obter um diagnóstico definitivo desta patologia antes da morte. Deste modo, a descoberta de um biomarcador precoce para esta doença é imprescindível, a fim de se tentar evitar a progressão da mesma. A disfunção olfativa é um dos primeiros sintomas da Doença de Alzheimer, estando presente na fase pré-clínica. Os testes ao olfato são não invasivos, baratos e fáceis de realizar, não dependendo dos médicos especialistas ou das análises laboratoriais. Por essa razão, o olfato é um possível bom biomarcador desta doença, podendo permitir o seu diagnóstico precoce e consequentemente, o acesso a melhores intervenções terapêuticas.
Alzheimer’s disease is a very common neurodegenerative disease and the main cause of dementia worldwide. Its prevalence is increasing across the years and until now it is still not possible to have a definitive diagnosis of this disease until after death. Therefore, it is very importante to develop a new ealry biomarker for this pathology, in order to try to prevent its progression. Olfactory dysfunction is one of the earliest symptoms of Alzheimer’s disease, being presente even in a pre-clinical setting. Olfactory tests are non-invasive, cheap, easy to perform and not reliant on specialist clinicians or laboratory analysis. Thus, smell could potentially be a suitable biomarker for Alzheimer’s, allowing for an early diagnosis and consequently access to better therapeutic interventions.
Alzheimer’s disease is a very common neurodegenerative disease and the main cause of dementia worldwide. Its prevalence is increasing across the years and until now it is still not possible to have a definitive diagnosis of this disease until after death. Therefore, it is very importante to develop a new ealry biomarker for this pathology, in order to try to prevent its progression. Olfactory dysfunction is one of the earliest symptoms of Alzheimer’s disease, being presente even in a pre-clinical setting. Olfactory tests are non-invasive, cheap, easy to perform and not reliant on specialist clinicians or laboratory analysis. Thus, smell could potentially be a suitable biomarker for Alzheimer’s, allowing for an early diagnosis and consequently access to better therapeutic interventions.
Description
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2020
Keywords
Doença de Alzheimer Disfunção olfativa Biomarcador Otorrinolaringologia