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Índices inflamatórios no hemograma de doentes com cancro do pulmão
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Resumo(s)
De acordo com dados da Organização Mundial de Saúde (OMS) o cancro do pulmão é uma das doenças oncológicas com maior número de casos anuais e a principal causa de morte por cancro a nível mundial. A crescente incidência deste cancro exige o estudo dos cofatores de carcinogénese, com impacto no desenvolvimento, tratamento e prognóstico da doença. Alguns destes cofatores implicados no cancro do pulmão são de carácter ambiental, do microbioma humano e de infeções carcinogénicas. Assim, estando os estados infeciosos relacionados com inflamação crónica, torna-se necessário apurar a associação entre os fatores de inflamação crónica sistémica em doentes com cancro do pulmão, com desenvolvimento da doença através de infeções carcinogénicas. Desta forma, esta dissertação pretende, de uma forma observacional e retrospetiva, analisar os elementos sistémicos no hemograma de doentes com cancro do pulmão, nomeadamente os componentes inflamatórios, que facilitam a replicação celular e consequente mutação genética, neste grupo de doentes. Para tal utilizam-se como marcadores vários índices inflamatórios, relacionando estes com a alteração no balanço entre inflamação e imunidade dos indivíduos com patologia oncológica pulmonar. De acordo com a bibliografia disponível até ao momento, este trabalho evidencia a tendência relativa à associação entre valores superiores de todos os índices inflamatórios (à exceção de LMR) e o cancro do pulmão e piores desfechos desta patologia. Adicionalmente recomendam-se estudos com uma amostragem superior para maior robustez da relação entre os fatores inflamatórios e a neoplasia pulmonar.
to the World Health Organization (WHO), lung cancer is the oncologic disease with the larger number of annual cases detected, and it is a major cause of death by oncologic diseases worldwide. The increasing incidence of lung cancer requires the study of its carcinogenesis’ cofactors with impact in the development, treatment, and prognosis of the disease. Some of the cofactors implicated in lung cancer are associated with the environment, human microbiome, and carcinogenic infections with agents. Thus, since infectious status relates with chronic inflammation it becomes pertinent to understand the association between chronic systemic inflammation factors in lung cancer patients, particularly non-smokers that developed the disease through carcinogenic infections. Hence, this study, from an observational and retrospective way, aims to analyze the systemic factors on the hemogram of lung cancer patients, namely inflammatory components that facilitate cellular replication and consequently genetic mutation, in this group of patients. For that purpose, inflammatory indexes calculated from the patients’ total blood count were used as markers, linking their values to balance change between inflammation and immunity status of individuals with lung cancer. According to the most up to date literature available, this study reflects the tendency of associating higher inflammatory indexes’ values (except LMR) with lung cancer and its worst outcomes. Additionally, we recommend further studies with a higher number of samples to further improve statical links between the inflammatory factors and pulmonary malignancy.
to the World Health Organization (WHO), lung cancer is the oncologic disease with the larger number of annual cases detected, and it is a major cause of death by oncologic diseases worldwide. The increasing incidence of lung cancer requires the study of its carcinogenesis’ cofactors with impact in the development, treatment, and prognosis of the disease. Some of the cofactors implicated in lung cancer are associated with the environment, human microbiome, and carcinogenic infections with agents. Thus, since infectious status relates with chronic inflammation it becomes pertinent to understand the association between chronic systemic inflammation factors in lung cancer patients, particularly non-smokers that developed the disease through carcinogenic infections. Hence, this study, from an observational and retrospective way, aims to analyze the systemic factors on the hemogram of lung cancer patients, namely inflammatory components that facilitate cellular replication and consequently genetic mutation, in this group of patients. For that purpose, inflammatory indexes calculated from the patients’ total blood count were used as markers, linking their values to balance change between inflammation and immunity status of individuals with lung cancer. According to the most up to date literature available, this study reflects the tendency of associating higher inflammatory indexes’ values (except LMR) with lung cancer and its worst outcomes. Additionally, we recommend further studies with a higher number of samples to further improve statical links between the inflammatory factors and pulmonary malignancy.
Descrição
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2024
Palavras-chave
Cancro do pulmão Inflamação Índices inflamatórios Hemograma