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Estudo preliminar da eficácia das sementes de Trigonella foenum-graecum L. (feno grego) no tratamento da SUGE (Síndrome de Úlcera Gástrica Equina)
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Resumo(s)
A alta prevalência de úlceras gástricas em cavalos e o efeito negativo destas na performance, em conjunto com o elevado custo económico do tratamento farmacológico, faz com que seja desejável encontrar alternativas mais acessíveis a este. Recentemente, devido à fácil acessibilidade e às suas potenciais capacidades terapêuticas, o interesse no uso de plantas tem vindo a aumentar.
O objetivo deste trabalho foi investigar o efeito do extrato aquoso das sementes de feno grego (Trigonella foenum-graecum L.), em equinos com Síndrome de Úlcera Gástrica Equina (SUGE). No estudo foram incluídos dez cavalos, dos quais sete foram colocados no grupo de tratamento e três no grupo controlo. Durante 28 dias, foi administrado ao grupo de tratamento 400 ml do extrato aquoso. Através de exames gastroscópicos, no dia 0 e 28, foi avaliado o grau das lesões e registados os valores de pH do suco gástrico.
A média do score de classificação das ulcerações da mucosa glandular foi significativamente mais baixa no grupo de cavalos tratados, comparada com a do grupo de controlo (P = 0,018). Já para a média de classificação da mucosa não glandular não se registaram diferenças significativas entre estes dois grupos (P = 0,648). Registou-se também uma diferença significativa dos valores de pH do suco gástrico entre os cavalos do grupo de tratamento e do grupo de controlo (P = 0,03).
A administração do extrato aquoso das sementes de Trigonella foenum-graecum L. demonstrou eficácia no tratamento da Doença Gástrica Glandular Equina e tem a capacidade de prevenir a descida do pH do suco gástrico. Contudo, não teve efeito no tratamento da Doença Gástrica Escamosa Equina.
ABSTRACT - Preliminary study of the effect of Trigonella foenum-graecum L. (fenugreek) on the treatment of EGUS (Equine Gastric Ulcer Syndrome) - The high prevalence of gastric ulcers in horses and its negative effect on performance, together with the high economic cost of the pharmacological treatment, makes it desirable to find more affordable alternatives. Recently, there has been an increased interest in the use of botanicals because of their easy accessibility and their potential therapeutic properties. The aim of this study was to investigate the effect of fenugreek seeds (Trigonella foenum-graecum L.) aqueous extract on gastric ulcers in horses. Ten horses entered the study, of which seven were placed in the treatment group and three in the control group. For twenty-eight days, 400ml of the extract was administered to the treatment group. After this period, all horses were re-evaluated. Using gastroscopic examinations (days 0 and 28), the gastric ulcer scores were evaluated and the gastric juice pH measured. Mean glandular gastric ulcer score was significantly lower in horses treated with the fenugreek seeds aqueous extract compared with the untreated control horses (P = 0,018). However, mean nonglandular gastric ulcer score was not significantly different between the horses from the treatment group and the ones from the control group (P = 0,648). There was also a significant difference between gastric juice pH in the treated horses and the horses from the control group. Trigonella foenum-graecum L. seed aqueous extract fed to horses showed efficacy in the treatment of the Equine Glandular Gastric Disease and has the capability to prevent the decrease of the gastric juice pH. However, it did not show efficacy in the treatment of the Equine Squamous Gastric Disease.
ABSTRACT - Preliminary study of the effect of Trigonella foenum-graecum L. (fenugreek) on the treatment of EGUS (Equine Gastric Ulcer Syndrome) - The high prevalence of gastric ulcers in horses and its negative effect on performance, together with the high economic cost of the pharmacological treatment, makes it desirable to find more affordable alternatives. Recently, there has been an increased interest in the use of botanicals because of their easy accessibility and their potential therapeutic properties. The aim of this study was to investigate the effect of fenugreek seeds (Trigonella foenum-graecum L.) aqueous extract on gastric ulcers in horses. Ten horses entered the study, of which seven were placed in the treatment group and three in the control group. For twenty-eight days, 400ml of the extract was administered to the treatment group. After this period, all horses were re-evaluated. Using gastroscopic examinations (days 0 and 28), the gastric ulcer scores were evaluated and the gastric juice pH measured. Mean glandular gastric ulcer score was significantly lower in horses treated with the fenugreek seeds aqueous extract compared with the untreated control horses (P = 0,018). However, mean nonglandular gastric ulcer score was not significantly different between the horses from the treatment group and the ones from the control group (P = 0,648). There was also a significant difference between gastric juice pH in the treated horses and the horses from the control group. Trigonella foenum-graecum L. seed aqueous extract fed to horses showed efficacy in the treatment of the Equine Glandular Gastric Disease and has the capability to prevent the decrease of the gastric juice pH. However, it did not show efficacy in the treatment of the Equine Squamous Gastric Disease.
Descrição
Dissertação de Mestrado Integrado em Medicina Veterinária
Palavras-chave
cavalo feno grego gastroscopia SUGE Trigonella foenum-graecum L. úlcera gástrica EGUS fenugreek gastric ulcer gastroscopy horse
Contexto Educativo
Citação
Craveiro, I.V.A. (2017). Estudo preliminar da eficácia das sementes de Trigonella foenum-graecum L. (feno grego) no tratamento da SUGE (Síndrome de Úlcera Gástrica Equina). Dissertação de mestrado. Universidade de Lisboa, Faculdade de Medicina Veterinária, Lisboa.
Editora
Universidade de Lisboa, Faculdade de Medicina Veterinária