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Advisor(s)
Abstract(s)
O linfoma maligno canino é um grupo heterogéneo de neoplasias com origem nas células
linfóides, podendo atingir praticamente todas as regiÔes do organismo.
A presente dissertação refere-se ao perĂodo de Setembro de 2008 a Junho de 2009, durante o
qual foi desenvolvida a componente prĂĄtica do EstĂĄgio Curricular de Mestrado Integrado, no
Hospital Escolar da FMV, de Setembro 2008 a Fevereiro de 2009. Durante este perĂodo
procedeu-se ao estudo de linfoma maligno multicĂȘntrico em 8 canĂdeos que evidenciaram
linfadenomegĂĄlia ao exame fĂsico e/ou exames citolĂłgicos ou histolĂłgicos positivos para
linfoma maligno. O diagnóstico da doença foi realizado por anålise citológica de linfonodo
(n=7), baço (n=2) e medula óssea (n=1) e por exame histológico hepåtico (n=1).
Adicionalmente realizaram-se exames complementares, nomeadamente a radiografia (n=6) e
a ultrasonografia (n=6). Os 8 canĂdeos foram distribuĂdos pelos estadios clĂnicos da OMS
sendo que 4 se enquadravam no estadio III, 3 no estadio IV e 1 no estadio V.
Os sinais e sintomas clĂnicos mais consistentes com doença foram a linfadenomegĂĄlia (n=7),
perda de peso acentuada (n=5) e anorexia (n=4). Relativamente às alteraçÔes hematológicas, 4
canĂdeos apresentavam anemia.
O tratamento quimioterĂĄpico baseado no protocolo CHOP de 19 semanas foi realizado em 4
canĂdeos. Dos restantes 4 animais, 3 foram submetidos a prednisolona e 1 nĂŁo recebeu
qualquer tipo de terapĂȘutica. A mortalidade e morbilidade foram bastante elevadas nos 4
Ășltimos casos. As alteraçÔes hematolĂłgicas foram a causa mais prevalente para o adiamento
de algumas sessÔes de quimioterapia.
Contudo, apesar da presença de efeitos secundĂĄrios para o animal e dos possĂveis riscos para a
saĂșde pĂșblica, os efeitos benĂ©ficos do uso de quimioterĂĄpicos parece sobrepor-se aos
potenciais riscos envolvidos.
Duma maneira geral, os canĂdeos responderam bem Ă terapĂȘutica quimioterĂĄpica mais
complexa e os proprietĂĄrios demonstraram-se satisfeitos com os resultados obtidos. Assim,
tendo em conta que o linfoma maligno canino Ă© dos tumores mais gratificantes de abordar
com quimioterapia deve ser estabelecida uma correcta relação com os proprietårios, de forma
a aumentar a adesĂŁo ao tratamento.
ABSTRACT - MALIGNANT MULTICENTRIC LYMPHOMA IN DOG - The canine malignant lymphoma is a heterogeneous group of neoplasias whose origin is in lymphoreticular cells and can virtually reach every region of the organism. This thesis covers the period September 2008 to June 2009, during which took place the curricular training of the Integrated Master degree in Veterinary Medicine, at the FMV Teaching Hospital, September 2008 to February 2009. During this period there has been a study of malignant multicentric lymphoma in 8 dogs, these showed lymphadenomegaly at the physical exam and/or were positive to cytologic or histologic examination for malignant lymphoma. The diagnosis of the disease was made by cytological examination of lymph nodes (n = 7), spleen (n = 2), bone marrow (n = 1) and liver histology (n = 1). They were made some additional tests, including radiography (n = 6) and ultrasound (n = 6). The 8 dogs were distributed by the WHO clinical stage, 4 of which were in stage III and the other in stage IV. The clinical signs and symptoms more consistent with the disease were lymphadenomegaly (n = 7), severe weight loss (n = 5) and anorexia (n = 4). Anemia was found in 4 dogs at CBC count. The CHOP chemotherapy protocol of 19 weeks was conducted in 4 dogs. In the remaining 4 animals, 3 were submitted to prednisolone and 1 did not receive any therapy. The rate of mortality and morbidity was high in the last two cases. The hematologic toxicity was the most prevalent cause for the postponement of some chemotherapy sessions. However, despite the presence of side effects to the animal and possible risks to public health, the beneficial effects of the use of chemotherapy seems to overlap the potential risks involved. In general, dogs had a good response to chemotherapy and owners seemed to be satisfied with the results. The canine malignant lymphoma is one of the most rewarding tumors to treat with chemotherapy. Therefore, a proper relationship with the owners is very important in order to increase adherence to treatment.
ABSTRACT - MALIGNANT MULTICENTRIC LYMPHOMA IN DOG - The canine malignant lymphoma is a heterogeneous group of neoplasias whose origin is in lymphoreticular cells and can virtually reach every region of the organism. This thesis covers the period September 2008 to June 2009, during which took place the curricular training of the Integrated Master degree in Veterinary Medicine, at the FMV Teaching Hospital, September 2008 to February 2009. During this period there has been a study of malignant multicentric lymphoma in 8 dogs, these showed lymphadenomegaly at the physical exam and/or were positive to cytologic or histologic examination for malignant lymphoma. The diagnosis of the disease was made by cytological examination of lymph nodes (n = 7), spleen (n = 2), bone marrow (n = 1) and liver histology (n = 1). They were made some additional tests, including radiography (n = 6) and ultrasound (n = 6). The 8 dogs were distributed by the WHO clinical stage, 4 of which were in stage III and the other in stage IV. The clinical signs and symptoms more consistent with the disease were lymphadenomegaly (n = 7), severe weight loss (n = 5) and anorexia (n = 4). Anemia was found in 4 dogs at CBC count. The CHOP chemotherapy protocol of 19 weeks was conducted in 4 dogs. In the remaining 4 animals, 3 were submitted to prednisolone and 1 did not receive any therapy. The rate of mortality and morbidity was high in the last two cases. The hematologic toxicity was the most prevalent cause for the postponement of some chemotherapy sessions. However, despite the presence of side effects to the animal and possible risks to public health, the beneficial effects of the use of chemotherapy seems to overlap the potential risks involved. In general, dogs had a good response to chemotherapy and owners seemed to be satisfied with the results. The canine malignant lymphoma is one of the most rewarding tumors to treat with chemotherapy. Therefore, a proper relationship with the owners is very important in order to increase adherence to treatment.
Description
Dissertação de Mestrado Integrado em Medicina Veterinåria
Keywords
Linfoma maligno multicĂȘntrico CanĂdeo Citologia Quimioterapia Malignant multicentric lymphoma Dogs Cytology Chemotherapy
Pedagogical Context
Citation
Proença, A.R.S.G. (2009). Linfoma maligno multicĂȘntrico canino. Dissertação de Mestrado. Universidade TĂ©cnica de Lisboa, Faculdade de Medicina VeterinĂĄria, Lisboa
Publisher
Universidade TĂ©cnica de Lisboa. Faculdade de Medicina VeterinĂĄria