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An artificial CO-releasing metalloprotein built by histidine-selective metallation
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Orientador(es)
Resumo(s)
We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)2(H2O)4](2+) reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33. The artificial, non-toxic interleukin (IL)-8-Ru(II)(CO)2 metalloprotein retained IL-8-dependent neutrophil chemotactic activity and was shown to spontaneously release CO in live cells.
Descrição
This journal is © The Royal Society of Chemistry 2015. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.
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Contexto Educativo
Citação
Chem Commun (Camb). 2015 Mar 7;51(19):3993-3996
Editora
Royal Society of Chemistry