Publication
Chitin-Glucan Complex Hydrogels: Optimization of Gel Formation and Demonstration of Drug Loading and Release Ability
| dc.contributor.author | Araújo, Diana | |
| dc.contributor.author | Rodrigues, Thomas | |
| dc.contributor.author | Delgado Alves, Vitor | |
| dc.contributor.author | Freitas, Filomena | |
| dc.date.accessioned | 2022-03-03T11:24:07Z | |
| dc.date.available | 2022-03-03T11:24:07Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Chitin-glucan complex (CGC) hydrogels were fabricated through a freeze–thaw procedure for biopolymer dissolution in NaOH 5 mol/L, followed by a dialysis step to promote gelation. Compared to a previously reported methodology that included four freeze–thaw cycles, reducing the number of cycles to one had no significant impact on the hydrogels’ formation, as well as reducing the total freezing time from 48 to 18 h. The optimized CGC hydrogels exhibited a high and nearly spontaneous swelling ratio (2528 +- 68%) and a water retention capacity of 55 +- 3%, after 2 h incubation in water, at 37 ºC. Upon loading with caffeine as a model drug, an enhancement of the mechanical and rheological properties of the hydrogels was achieved. In particular, the compressive modulus was improved from 23.0 +-0.89 to 120.0 +- 61.64 kPa and the storage modulus increased from 149.9 +- 9.8 to 315.0 +- 76.7 kPa. Although the release profile of caffeine was similar in PBS and NaCl 0.9% solutions, the release rate was influenced by the solutions’ pH and ionic strength, being faster in the NaCl solution. These results highlight the potential of CGC based hydrogels as promising structures to be used as drug delivery devices in biomedical applications | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Araújo, D.; Rodrigues, T.; Alves, V.D.; Freitas, F. Chitin-Glucan Complex Hydrogels: Optimization of Gel Formation and Demonstration of Drug Loading and Release Ability. Polymers 2022, 14, 785 | pt_PT |
| dc.identifier.doi | https:// doi.org/10.3390/polym14040785 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.5/23705 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | Linking Landscape, Environment, Agriculture and Food | |
| dc.relation | Linking Landscape, Environment, Agriculture and Food | |
| dc.relation | Transdermal delivery systems based on natural polymeric biomaterials | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | hydrogels | pt_PT |
| dc.subject | chitin-glucan complex | pt_PT |
| dc.subject | freeze–thaw cycles | pt_PT |
| dc.subject | swelling ratio | pt_PT |
| dc.subject | caffeine | pt_PT |
| dc.subject | drug delivery | pt_PT |
| dc.title | Chitin-Glucan Complex Hydrogels: Optimization of Gel Formation and Demonstration of Drug Loading and Release Ability | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Linking Landscape, Environment, Agriculture and Food | |
| oaire.awardTitle | Linking Landscape, Environment, Agriculture and Food | |
| oaire.awardTitle | Transdermal delivery systems based on natural polymeric biomaterials | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04129%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04129%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F140829%2F2018/PT | |
| oaire.citation.title | Polymers | pt_PT |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Delgado Alves | |
| person.givenName | Vitor | |
| person.identifier | 1916677 | |
| person.identifier.ciencia-id | 2E1E-6918-4DB3 | |
| person.identifier.orcid | 0000-0002-4117-5582 | |
| person.identifier.scopus-author-id | 24536716000 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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