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Chitin-Glucan Complex Hydrogels: Optimization of Gel Formation and Demonstration of Drug Loading and Release Ability

2022Journal article Open access
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dc.contributor.authorAraújo, Diana
dc.contributor.authorRodrigues, Thomas
dc.contributor.authorDelgado Alves, Vitor
dc.contributor.authorFreitas, Filomena
dc.date.accessioned2022-03-03T11:24:07Z
dc.date.available2022-03-03T11:24:07Z
dc.date.issued2022
dc.description.abstractChitin-glucan complex (CGC) hydrogels were fabricated through a freeze–thaw procedure for biopolymer dissolution in NaOH 5 mol/L, followed by a dialysis step to promote gelation. Compared to a previously reported methodology that included four freeze–thaw cycles, reducing the number of cycles to one had no significant impact on the hydrogels’ formation, as well as reducing the total freezing time from 48 to 18 h. The optimized CGC hydrogels exhibited a high and nearly spontaneous swelling ratio (2528 +- 68%) and a water retention capacity of 55 +- 3%, after 2 h incubation in water, at 37 ºC. Upon loading with caffeine as a model drug, an enhancement of the mechanical and rheological properties of the hydrogels was achieved. In particular, the compressive modulus was improved from 23.0 +-0.89 to 120.0 +- 61.64 kPa and the storage modulus increased from 149.9 +- 9.8 to 315.0 +- 76.7 kPa. Although the release profile of caffeine was similar in PBS and NaCl 0.9% solutions, the release rate was influenced by the solutions’ pH and ionic strength, being faster in the NaCl solution. These results highlight the potential of CGC based hydrogels as promising structures to be used as drug delivery devices in biomedical applicationspt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAraújo, D.; Rodrigues, T.; Alves, V.D.; Freitas, F. Chitin-Glucan Complex Hydrogels: Optimization of Gel Formation and Demonstration of Drug Loading and Release Ability. Polymers 2022, 14, 785pt_PT
dc.identifier.doihttps:// doi.org/10.3390/polym14040785pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/23705
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationLinking Landscape, Environment, Agriculture and Food
dc.relationLinking Landscape, Environment, Agriculture and Food
dc.relationTransdermal delivery systems based on natural polymeric biomaterials
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjecthydrogelspt_PT
dc.subjectchitin-glucan complexpt_PT
dc.subjectfreeze–thaw cyclespt_PT
dc.subjectswelling ratiopt_PT
dc.subjectcaffeinept_PT
dc.subjectdrug deliverypt_PT
dc.titleChitin-Glucan Complex Hydrogels: Optimization of Gel Formation and Demonstration of Drug Loading and Release Abilitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLinking Landscape, Environment, Agriculture and Food
oaire.awardTitleLinking Landscape, Environment, Agriculture and Food
oaire.awardTitleTransdermal delivery systems based on natural polymeric biomaterials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04129%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04129%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F140829%2F2018/PT
oaire.citation.titlePolymerspt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameDelgado Alves
person.givenNameVitor
person.identifier1916677
person.identifier.ciencia-id2E1E-6918-4DB3
person.identifier.orcid0000-0002-4117-5582
person.identifier.scopus-author-id24536716000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery8d1a8489-8789-4569-89e2-0bade23dd945
relation.isProjectOfPublication242ffd71-e775-4d6a-8b04-1559d7f37ad1
relation.isProjectOfPublication68ef0aed-47b8-469e-819f-7175024862e9
relation.isProjectOfPublication08cf1ce2-e2e4-4e32-bbaa-71a53e3eea63
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