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Frequency of residual combined dyslipidemia and hypertriglyceridemia in patients with coronary heart disease in 13 countries across 6 WHO Regions: results from INTERASPIRE

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dc.contributor.authorSantos, Raul D.
dc.contributor.authorRay, Kausik K.
dc.contributor.authorDe Bacquer, Dirk
dc.contributor.authorJennings, Catriona
dc.contributor.authorKotseva, Kornelia
dc.contributor.authorRydén, Lars
dc.contributor.authorLip, Gregory Y. H.
dc.contributor.authorErlund, Iris
dc.contributor.authorGanly, Sandra
dc.contributor.authorVihervaara, Terhi
dc.contributor.authorAdamska, Agnieszka
dc.contributor.authorAbreu, Ana
dc.contributor.authorAlmahmeed, Wael
dc.contributor.authorAmbari, Ade Meidian
dc.contributor.authorGe, Junbo
dc.contributor.authorHasan-Ali, Hosam
dc.contributor.authorHuo, Yong
dc.contributor.authorJankowski, Piotr
dc.contributor.authorJimenez, Rodney M.
dc.contributor.authorLi, Yong
dc.contributor.authorMahmood Zuhdi, Ahmad Syadi
dc.contributor.authorMakubi, Abel
dc.contributor.authorMbakwem, Amam Chinyere
dc.contributor.authorMbau, Lilian
dc.contributor.authorNavarro Estrada, Jose Luis
dc.contributor.authorOgah, Okechukwu Samuel
dc.contributor.authorOgola, Elijah Nyainda
dc.contributor.authorQuintero–Baiz, Adalberto
dc.contributor.authorSani, Mahmoud Umar
dc.contributor.authorSosa Liprandi, Maria Ines
dc.contributor.authorChieh Tan, Jack Wei
dc.contributor.authorUrina-Triana, Miguel Alberto
dc.contributor.authorYeo, Tee Joo
dc.contributor.authorWood, David
dc.contributor.authorMcEvoy, John William
dc.contributor.authorLibby, Peter
dc.date.accessioned2025-05-08T10:40:23Z
dc.date.available2025-05-08T10:40:23Z
dc.date.issued2025
dc.description© 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.pt_PT
dc.description.abstractBackground and aims: Hypertriglyceridemia (HTG) is independently associated with risk of atherosclerotic events, even when LDL-cholesterol levels appear controlled. This INTERASPIRE study determined the frequency of HTG and residual combined dyslipidemia and their related factors in patients with coronary heart disease (CHD) from 13 countries across six World Health Organization (WHO) regions. Methods: Participants with CHD underwent a standardized study interview and examination, including a centralized analysis of fasting blood samples. Elevated triglyceride (TG) and LDL-cholesterol were defined as ≥ 1.7 mmol/L and 1.8 mmol/L, respectively. Elevation in both was considered combined dyslipidemia. Results: Lipid profiles were available for 4069 patients. The mean age was 60.1 years (21.1 % women, 12.6 % smokers, 24 % obesity by body mass index [BMI], 61 % hypertension, and 44 % self-reported diabetes). Participants were evaluated 1.05 (0.76-1.45) years after their index CHD hospitalization. Overall, 12.7 % used no lipid-lowering therapies (LLT), 50.0 % used high-dose statins, and 11.8 % used combination therapies. Specific TG-lowering therapies were used by 2.3 %. One-third of patients had HTG, and 24.6 % had combined dyslipidemia. HTG was seen in all countries, but median TG values varied, with higher values among those not using LLT. HTG was independently associated with female sex, smoking, BMI, blood pressure, and LDL-cholesterol. HTG was inversely associated with HDL-cholesterol. Conclusions: HTG and residual combined dyslipidemia are common, although with wide variability between countries. A healthier lifestyle, weight reduction, greater use of combination therapy, and evidence-based TG-lowering treatments are necessary to reduce the risks of HTG and combined dyslipidemia.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAtherosclerosis. 2025 Apr 24:405:119215pt_PT
dc.identifier.doi10.1016/j.atherosclerosis.2025.119215pt_PT
dc.identifier.eissn1879-1484
dc.identifier.issn0021-9150
dc.identifier.urihttp://hdl.handle.net/10400.5/100479
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/atherosclerosispt_PT
dc.subjectCombined dyslipidemiapt_PT
dc.subjectCoronary heart diseasept_PT
dc.subjectFemale sexpt_PT
dc.subjectObesitypt_PT
dc.subjectSmokingpt_PT
dc.subjectStatinspt_PT
dc.subjectTriglyceridespt_PT
dc.titleFrequency of residual combined dyslipidemia and hypertriglyceridemia in patients with coronary heart disease in 13 countries across 6 WHO Regions: results from INTERASPIREpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleAtherosclerosispt_PT
oaire.citation.volume405pt_PT
person.familyNameAbreu
person.givenNameAna
person.identifier.ciencia-id881A-1343-A491
person.identifier.orcid0000-0003-0786-7830
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0881e2c9-e3e9-4eff-b1e1-475ca2dfa3fd
relation.isAuthorOfPublication.latestForDiscovery0881e2c9-e3e9-4eff-b1e1-475ca2dfa3fd

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