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Optical coherence tomography angiography study of the retinal vascular plexuses in type 1 diabetes without retinopathy

2019Journal article Restricted access
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dc.contributor.authorSousa, David Cordeiro
dc.contributor.authorLeal, Ines
dc.contributor.authorMoreira, Susana
dc.contributor.authorVale, Sónia do
dc.contributor.authorSilva-Herdade, Ana S.
dc.contributor.authorDionísio, Patrícia
dc.contributor.authorCastanho, Miguel A. R. B.
dc.contributor.authorPinto, Luis
dc.contributor.authorMarques-Neves, Carlos
dc.date.accessioned2023-04-21T11:25:31Z
dc.date.available2023-04-21T11:25:31Z
dc.date.issued2019
dc.description© The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2019pt_PT
dc.description.abstractAim Previous data suggest the existence of retinal vascular changes and impaired autoregulation in the very early stages of diabetic retinopathy (DR). We compared the retinal plexuses between patients with type 1 diabetes (T1D) without DR and a demographically similar healthy cohort, using optical coherence tomography angiography (OCT-A). Methods Patients with T1D and no signs of DR were prospectively recruited from an outpatient clinic. Using OCT-A (AngioVue®), the parafoveal superficial (SCP) and deep (DPC) capillary plexus as well as the foveal avascular zone (FAZ) and perimeter were gathered. Mean comparison tests and linear regression analysis were used as statistical tests (STATA v14). Results Studied population included 48 subjects (24 T1D). The analysis of SCP revealed an attenuation of the capillary network compared with the control group in both parafoveal (51.8 ± 4.5 vs. 55.8 ± 3.2, p < 0.001) and perifoveal (51.9 ± 3.3 vs. 53.9 ± 1.9, p = 0.01) regions. A similar finding was observed in the DCP for both parafoveal (56.4 ± 4.3 vs. 60.4 ± 2.2, p < 0.001) and perifoveal (54.7 ± 3.9 vs. 60.8 ± 3.4, p = 0.001) sectors. Also, a longer time since T1D diagnosis was associated with a larger FAZ area (p = 0.055) and perimeter (p = 0.03). Conclusions Significant differences in the retinal microvasculature were observed between healthy subjects and T1D patients using OCT-A, even before clinically detectable disease on fundus biomicroscopy.pt_PT
dc.description.sponsorshipThe authors would like to thank AstraZeneca Foundation/Faculty of Medicine of the University of Lisboa.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEye 34, 307–311 (2020)pt_PT
dc.identifier.doi10.1038/s41433-019-0513-0pt_PT
dc.identifier.eissn2052-4617
dc.identifier.issn1465-931X
dc.identifier.urihttp://hdl.handle.net/10451/57217
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMA Healthcarept_PT
dc.relation.publisherversionhttps://www.nature.com/eye/pt_PT
dc.titleOptical coherence tomography angiography study of the retinal vascular plexuses in type 1 diabetes without retinopathypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage311pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage307pt_PT
oaire.citation.titleEyept_PT
oaire.citation.volume34pt_PT
person.familyNameSousa
person.familyNameLeal
person.familyNameMoreira
person.familyNamedo Vale
person.familyNameSilva-Herdade
person.familyNameCastanho
person.familyNameAbegão Pinto
person.familyNameMarques Neves
person.givenNameDavid Cordeiro
person.givenNameInes
person.givenNameSusana
person.givenNameSónia
person.givenNameAna S.
person.givenNameMiguel
person.givenNameLuis
person.givenNameCarlos
person.identifier707480
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person.identifier.ciencia-idF216-4AFA-8E65
person.identifier.ciencia-idC119-D580-13D6
person.identifier.orcid0000-0002-7680-0325
person.identifier.orcid0000-0001-9622-8779
person.identifier.orcid0000-0002-0219-7092
person.identifier.orcid0000-0001-9287-4095
person.identifier.orcid0000-0002-3023-1315
person.identifier.orcid0000-0001-7891-7562
person.identifier.orcid0000-0002-9960-7579
person.identifier.orcid0000-0002-3842-2466
person.identifier.ridA-6192-2015
person.identifier.ridB-2735-2019
person.identifier.scopus-author-id57188627862
person.identifier.scopus-author-id57187966600
person.identifier.scopus-author-id15825086700
person.identifier.scopus-author-id56605575600
person.identifier.scopus-author-id6504812918
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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