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Advisor(s)
Abstract(s)
ABSTRACT - The dissemination of antimicrobial-resistance is a major global threat affecting both human
and animal health. Carbapenems are human use β-lactams of last resort; thus. the dissemination of
carbapenemase-producing (CP) bacteria creates severe limitations for the treatment of multidrugresistant bacteria in hospitalized patients. Even though carbapenems are not routinely used in
veterinary medicine, reports of infection or colonization by carbapenemase-producing Enterobacterales in companion animals are being reported. NDM-5 and OXA-48-like carbapenemases are
among the most frequently reported in companion animals. Like in humans, Escherichia coli and
Klebsiella pneumoniae are the most represented CP Enterobacterales found in companion animals,
alongside with Acinetobacter baumannii. Considering that the detection of carbapenemase-producing
Enterobacterales presents several difficulties, misdiagnosis of CP bacteria in companion animals
may lead to important animal and public-health consequences. It is of the upmost importance to
ensure an adequate monitoring and detection of CP bacteria in veterinary microbiology in order
to safeguard animal health and minimise its dissemination to humans and the environment. This
review encompasses an overview of the carbapenemase detection methods currently available, aiming to guide veterinary microbiologists on the best practices to improve its detection for clinical or
research purposes.
Description
Research Areas: Infectious Diseases ; Pharmacology & Pharmacy
Keywords
Companion animals Enterobacterales Carbapenemase detection methods
Pedagogical Context
Citation
da Silva JM, Menezes J, Marques C, Pomba CF. 2022. Companion Animals-An Overlooked and Misdiagnosed Reservoir of Carbapenem Resistance. Antibiotics 2022, 11(4):533. DOI: https://doi.org/10.3390/antibiotics11040533
Publisher
MDPI