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Excipientes para formulação DPI
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Orientador(es)
Resumo(s)
O ser humano utiliza diversas vias para administração de fármacos para tratamentos de diversas patologias. Umas dessas vias é a via pulmonar, a qual o Homem já utiliza há milhares de anos, através da inalação de substâncias que vão exercer ação farmacológica no organismo. Um dos tipos de dispositivos que foram desenvolvidos são os Dry Powder Inhaler (DPI’s), ou seja inaladores de pó seco. Mas o fármaco utilizado neste tipo de dispositivos necessita de excipientes que permitirão uma melhor administração, resultando num efeito terapêutico mais eficiente. Estes excipientes têm uma função importante pois ditam se o fármaco é administrado eficazmente, o que influencia o seu efeito terapêutico. Nesta monografia será abordada a temática dos excipientes utilizados em DPI’s, mais concretamente, lactose, manitol, glucose monohidratada, sorbitol, trealose, eritritol, ciclodextrinas, PLGA e hidroxiapatita.
Humans use various routes for drug administration to treat various pathologies. One of these pathways is the pulmonary pathway, which humans have been using for thousands of years, through the inhalation of substances that will exert pharmacological action in the body. One of the types of devices that have been developed are Dry Powder Inhaler (DPI's), ie dry powder inhalers. But the drug used in such devices needs excipients that will allow better administration, resulting in a more efficient therapeutic effect. These excipients play an important role as they dictate whether the drug is administered effectively, which influences its therapeutic effect. This monograph will address the topic of excipients used in DPIs, namely lactose, mannitol, glucose monohydrate, sorbitol, trehalose, erythritol, cyclodextrins, PLGA and hydroxyapatite.
Humans use various routes for drug administration to treat various pathologies. One of these pathways is the pulmonary pathway, which humans have been using for thousands of years, through the inhalation of substances that will exert pharmacological action in the body. One of the types of devices that have been developed are Dry Powder Inhaler (DPI's), ie dry powder inhalers. But the drug used in such devices needs excipients that will allow better administration, resulting in a more efficient therapeutic effect. These excipients play an important role as they dictate whether the drug is administered effectively, which influences its therapeutic effect. This monograph will address the topic of excipients used in DPIs, namely lactose, mannitol, glucose monohydrate, sorbitol, trehalose, erythritol, cyclodextrins, PLGA and hydroxyapatite.
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019
Palavras-chave
Dry powder inhaler Excipients Pulmonary drug delivery Devices Formulation Lungs Carriers. Mestrado Integrado - 2019