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Cardiovascular risk factors and clinical outcomes among patients hospitalized with COVID-19: findings from the World Heart Federation COVID-19 study

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dc.contributor.authorPrabhakaran, Dorairaj
dc.contributor.authorSingh, Kavita
dc.contributor.authorKondal, Dimple
dc.contributor.authorRaspail, Lana
dc.contributor.authorMohan, Bishav
dc.contributor.authorKato, Toru
dc.contributor.authorSarrafzadegan, Nizal
dc.contributor.authorTalukder, Shamim Hayder
dc.contributor.authorAkter, Shahin
dc.contributor.authorAmin, Mohammad Robed
dc.contributor.authorGoma, Fastone
dc.contributor.authorGomez-Mesa, Juan
dc.contributor.authorNtusi, Ntobeko
dc.contributor.authorInofomoh, Francisca
dc.contributor.authorDeora, Surender
dc.contributor.authorPhilippov, Evgenii
dc.contributor.authorSvarovskaya, Alla
dc.contributor.authorKonradi, Alexandra
dc.contributor.authorPuentes, Aurelio
dc.contributor.authorOgah, Okechukwu S.
dc.contributor.authorStanetic, Bojan
dc.contributor.authorIssa, Aurora
dc.contributor.authorThienemann, Friedrich
dc.contributor.authorJuzar, Dafsah
dc.contributor.authorZaidel, Ezequiel
dc.contributor.authorSheikh, Sana
dc.contributor.authorOjji, Dike
dc.contributor.authorLam, Carolyn S. P.
dc.contributor.authorGe, Junbo
dc.contributor.authorBanerjee, Amitava
dc.contributor.authorNewby, L. Kristin
dc.contributor.authorRibeiro, Antonio Luiz P.
dc.contributor.authorGidding, Samuel
dc.contributor.authorPinto, Fausto J.
dc.contributor.authorPerel, Pablo
dc.contributor.authorSliwa, Karen
dc.date.accessioned2022-07-18T16:44:12Z
dc.date.available2022-07-18T16:44:12Z
dc.date.issued2022
dc.description© 2022 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/ licenses/by/4.0/.pt_PT
dc.description.abstractBackground and aims: Limited data exist on the cardiovascular manifestations and risk factors in people hospitalized with COVID-19 from low- and middle-income countries. This study aims to describe cardiovascular risk factors, clinical manifestations, and outcomes among patients hospitalized with COVID-19 in low, lower-middle, uppermiddle- and high-income countries (LIC, LMIC, UMIC, HIC). Methods: Through a prospective cohort study, data on demographics and pre-existing conditions at hospital admission, clinical outcomes at hospital discharge (death, major adverse cardiovascular events (MACE), renal failure, neurological events, and pulmonary outcomes), 30-day vital status, and re-hospitalization were collected. Descriptive analyses and multivariable log-binomial regression models, adjusted for age, sex, ethnicity/income groups, and clinical characteristics, were performed. Results: Forty hospitals from 23 countries recruited 5,313 patients with COVID-19 (LIC = 7.1%, LMIC = 47.5%, UMIC = 19.6%, HIC = 25.7%). Mean age was 57.0 (±16.1) years, male 59.4%, pre-existing conditions included: hypertension 47.3%, diabetes 32.0%, coronary heart disease 10.9%, and heart failure 5.5%. The most frequently reported cardiovascular discharge diagnoses were cardiac arrest (5.5%), acute heart failure (3.8%), and myocardial infarction (1.6%). The rate of in-hospital deaths was 12.9% (N = 683), and post-discharge 30 days deaths was 2.6% (N = 118) (overall death rate 15.1%). The most common causes of death were respiratory failure (39.3%) and sudden cardiac death (20.0%). The predictors of overall mortality included older age (≥60 years), male sex, pre-existing coronary heart disease, renal disease, diabetes, ICU admission, oxygen therapy, and higher respiratory rates (p < 0.001 for each). Compared to Caucasians, Asians, Blacks, and Hispanics had almost 2–4 times higher risk of death. Further, patients from LIC, LMIC, UMIC versus. HIC had 2–3 times increased risk of death. Conclusions: The LIC, LMIC, and UMIC’s have sparse data on COVID-19. We provide robust evidence on COVID-19 outcomes in these countries. This study can help guide future health care planning for the pandemic globally.pt_PT
dc.description.sponsorshipDr. Kavita Singh is supported by the National Institutes of Health, Fogarty International Centre, USA; Emerging Global Leader grant award number: 1 K43 TW011164. Dr Antonio Luiz P. Ribeiro is supported in part by Brazilian Agencies CNPq (310679/2016-8 and 465518/2014-1), by FAPEMIG (PPM-00428-17) and CAPES (88887.507149/2020-00). Dr Karen Sliwa acknowledges support from the Hippocrate Foundation and the Medical Research Council South Africa. Friedrich Thienemann is supported by European and Developing Countries Clinical Trials Partnership (EDCTP) of the European Union.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGlobal Heart. 2022; 17(1): 40pt_PT
dc.identifier.doi10.5334/gh.1128pt_PT
dc.identifier.eissn2211-8179
dc.identifier.issn2211-8160
dc.identifier.urihttp://hdl.handle.net/10451/53850
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherUbiquity Presspt_PT
dc.relation.publisherversionhttps://globalheartjournal.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectMortalitypt_PT
dc.subjectCardiovascular diseasept_PT
dc.titleCardiovascular risk factors and clinical outcomes among patients hospitalized with COVID-19: findings from the World Heart Federation COVID-19 studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleGlobal Heartpt_PT
oaire.citation.volume17pt_PT
person.familyNamePinto
person.givenNameFausto J.
person.identifier1308889
person.identifier.ciencia-idC311-AEDD-6DBB
person.identifier.orcid0000-0002-8034-4529
person.identifier.ridG-9363-2015
person.identifier.scopus-author-id7102740158
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5f44176f-69f5-482c-83cd-ab94425a6ec3
relation.isAuthorOfPublication.latestForDiscovery5f44176f-69f5-482c-83cd-ab94425a6ec3

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