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Impairment of spatial working memory but preservation of recognition memory in female rats with spontaneous absence seizures

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dc.contributor.authorNeuparth-Sottomayor, Mariana
dc.contributor.authorMorais, Tatiana P.
dc.contributor.authorGood, Mark
dc.contributor.authorSebastião, Ana M
dc.contributor.authorDi Giovanni, Giuseppe
dc.contributor.authorCrunelli, Vincenzo
dc.contributor.authorVaz, Sandra H.
dc.date.accessioned2025-07-30T10:42:59Z
dc.date.available2025-07-30T10:42:59Z
dc.date.issued2025
dc.description© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.pt_PT
dc.description.abstractEpidemiological studies reveal gender-specific differences in epilepsy. Childhood absence epilepsy (CAE), which is more prevalent in females, is characterized by typical absence seizures (ASs) consisting of brief periods of unconsciousness, associated with 2.5-4 Hz spike-wave discharges (SWDs) in the electroencephalogram (EEG). Children with CAE often present neuropsychological comorbidities, including deficits in attention and executive function. In this study, we investigated anxiety-like behaviour and memory in female Genetic Absence Epilepsy Rat from Strasbourg (GAERS), a validated model of ASs, compared to Non-Epileptic Control (NEC) and Wistar rats. We found that female GAERS generally showed normal anxiety-like behaviour relative to both control strains, although some tests suggested a reduction in anxiety. Importantly, female GAERS showed impaired spatial working memory, while recognition memory was preserved. These findings when compared with previous data in males indicate that while anxiety levels in female GAERS are preserved as those of male GAERS, memory performance differs, with males showing impairments in both spatial working memory and recognition memory. These findings emphasize the importance of considering gender differences in both clinical and preclinical epilepsy research to better understand the neuropsychological comorbidities associates with ASs. This knowledge is crucial for the identification of gender-specific mechanism, as well as the development of gender-sensitive, personalized therapies targeting both seizures and associated cognitive impairments.pt_PT
dc.description.sponsorshipOpen access funding provided by FCT|FCCN (b-on). This work was supported by the Fundação para a Ciência e para a Tecnologia (FCT) (grant PTDC/MED-FAR/30933/2017 to AMS and MNS, 2023.01003.BD to MNS), by the International Society for Neurochemistry (Career Development Grant 2021 to SHV), the European Union (H2020-WIDESPREAD-05-2017-Twinning (EpiEpinet), grant agreement 952455, to AMS and SHV), the Malta Council for Science & Technology and the Foundation for Science and Technology (grant CanEpiRisk, to GDG), and the Ester Floridia Neuroscience Research Foundation (grant 1502 to VC).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeurochem Res. 2025 Jul 17;50(4):236pt_PT
dc.identifier.doi10.1007/s11064-025-04485-wpt_PT
dc.identifier.eissn1573-6903
dc.identifier.issn0364-3190
dc.identifier.urihttp://hdl.handle.net/10400.5/102533
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationHow do astrocytes control absence seizures and their comorbid cognitive deficits
dc.relationEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
dc.relation.publisherversionhttps://link.springer.com/journal/11064pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnxietypt_PT
dc.subjectComorbiditiespt_PT
dc.subjectEPMpt_PT
dc.subjectGAERS ratspt_PT
dc.subjectNEC ratspt_PT
dc.subjectNORpt_PT
dc.subjectWistar ratspt_PT
dc.subjectY mazept_PT
dc.titleImpairment of spatial working memory but preservation of recognition memory in female rats with spontaneous absence seizurespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHow do astrocytes control absence seizures and their comorbid cognitive deficits
oaire.awardTitleEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017/PTDC%2FMED-FAR%2F30933%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2023.01003.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/952455/EU
oaire.citation.issue236pt_PT
oaire.citation.titleNeurochemical Researchpt_PT
oaire.citation.volume50pt_PT
oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017
oaire.fundingStreamH2020
person.familyNameSerra de Sequeira Neuparth Sottomayor
person.familyNameSebastião
person.familyNameCrunelli
person.familyNameHenriques Vaz
person.givenNameMariana
person.givenNameAna M
person.givenNameVincenzo
person.givenNameSandra Cristina
person.identifier.ciencia-id6B1E-0623-D291
person.identifier.ciencia-idF112-55E8-E37E
person.identifier.ciencia-id4E1D-A063-A7E4
person.identifier.ciencia-id0E1C-952D-61BE
person.identifier.orcid0000-0002-2309-0171
person.identifier.orcid0000-0001-9030-6115
person.identifier.orcid0000-0001-7154-9752
person.identifier.orcid0000-0003-4258-9397
person.identifier.scopus-author-id7004409879
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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