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Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals

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dc.contributor.authorXue, Pei
dc.contributor.authorMerikanto, Ilona
dc.contributor.authorChung, Frances
dc.contributor.authorMorin, Charles M.
dc.contributor.authorEspie, Colin
dc.contributor.authorBjorvatn, Bjørn
dc.contributor.authorCedernaes, Jonathan
dc.contributor.authorLandtblom, Anne-Marie
dc.contributor.authorPenzel, Thomas
dc.contributor.authorDe Gennaro, Luigi
dc.contributor.authorHolzinger, Brigitte
dc.contributor.authorMatsui, Kentaro
dc.contributor.authorHrubos-Strøm, Harald
dc.contributor.authorKorman, Maria
dc.contributor.authorLeger, Damien
dc.contributor.authorMota-Rolim, Sérgio
dc.contributor.authorBolstad, Courtney J.
dc.contributor.authorNadorff, Michael
dc.contributor.authorPlazzi, Giuseppe
dc.contributor.authorReis, Cátia
dc.contributor.authorChan, Rachel Ngan Yin
dc.contributor.authorWing, Yun Kwok
dc.contributor.authorYordanova, Juliana
dc.contributor.authorBjelajac, Adrijana Koscec
dc.contributor.authorInoue, Yuichi
dc.contributor.authorPartinen, Markku
dc.contributor.authorDauvilliers, Yves
dc.contributor.authorBenedict, Christian
dc.date.accessioned2023-02-10T12:12:37Z
dc.date.available2023-02-10T12:12:37Z
dc.date.issued2023
dc.description© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.pt_PT
dc.description.abstractShort nighttime sleep duration impairs the immune response to virus vaccination, and long nighttime sleep duration is associated with poor health status. Thus, we hypothesized that short (<6 h) and long (>9 h) nighttime sleepers have a higher post-COVID risk than normal nighttime sleepers, despite two doses of mRNA vaccine (which has previously been linked to lower odds of long-lasting COVID-19 symptoms). Post-COVID was defined as experiencing at least one core COVID-19 symptom for at least three months (e.g., shortness of breath). Multivariate logistic regression adjusting for age, sex, BMI, and other factors showed in 9717 respondents (age span 18-99) that two mRNA vaccinations lowered the risk of suffering from post-COVID by about 21% (p < 0.001). When restricting the analysis to double-vaccinated respondents (n = 5918), short and long sleepers exhibited a greater post-COVID risk than normal sleepers (adjusted OR [95%-CI], 1.56 [1.29, 1.88] and 1.87 [1.32, 2.66], respectively). Among respondents with persistent sleep duration patterns during the pandemic compared to before the pandemic, short but not long sleep duration was significantly associated with the post-COVID risk (adjusted OR [95%-CI], 1.59 [1.24, 2.03] and 1.18 [0.70, 1.97], respectively). No significant association between sleep duration and post-COVID symptoms was observed in those reporting positive SARS-CoV-2 test results (n = 538). Our findings suggest that two mRNA vaccinations against SARS-CoV-2 are associated with a lower post-COVID risk. However, this protection may be less pronounced among those sleeping less than 6 h per night. Our findings warrant replication in cohorts with individuals with confirmed SARS-CoV-2 infection.pt_PT
dc.description.sponsorshipCB’s research is financially supported by the Swedish Brain Research Foundation [FO2022-0254]. PX’s research is financially supported by the Åke Wiberg Foundation [M22-0081]. MP’s research is is financially supported by Signe and Arne Gyllenberg Foundation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTransl Psychiatry. 2023 Feb 1;13(1):32pt_PT
dc.identifier.doi10.1038/s41398-023-02334-4pt_PT
dc.identifier.eissn2158-3188
dc.identifier.urihttp://hdl.handle.net/10451/56245
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.nature.com/tp/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titlePersistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individualspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleTranslational Psychiatrypt_PT
oaire.citation.volume13pt_PT
person.familyNamePeixinho Reis
person.givenNameCátia Cristina
person.identifier.ciencia-idC817-4B30-902F
person.identifier.orcid0000-0001-6585-3993
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication39014fe9-c831-4a22-ae3c-e464f35592cc
relation.isAuthorOfPublication.latestForDiscovery39014fe9-c831-4a22-ae3c-e464f35592cc

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