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Convergent neural correlates of prenatal exposure to air pollution and behavioral phenotypes of risk for internalizing and externalizing problems: potential biological and cognitive pathways

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dc.contributor.authorMargolis, Amy E.
dc.contributor.authorLiu, Ran
dc.contributor.authorConceição, Vasco A.
dc.contributor.authorRamphal, Bruce
dc.contributor.authorPagliaccio, David
dc.contributor.authorDeSerisy, Mariah L.
dc.contributor.authorKoe, Emily
dc.contributor.authorSelmanovic, Ena
dc.contributor.authorRaudales, Amarelis
dc.contributor.authorEmanet, Nur
dc.contributor.authorQuinn, Aurabelle E.
dc.contributor.authorBeebe, Beatrice
dc.contributor.authorPearson, Brandon L.
dc.contributor.authorHerbstman, Julie B.
dc.contributor.authorRauh, Virginia A.
dc.contributor.authorFifer, William P.
dc.contributor.authorFox, Nathan A.
dc.contributor.authorChampagne, Frances A.
dc.date.accessioned2022-06-07T15:59:57Z
dc.date.available2022-06-07T15:59:57Z
dc.date.issued2022
dc.description© 2022 Elsevier Ltd. All rights reserved.pt_PT
dc.description.abstractHumans are ubiquitously exposed to neurotoxicants in air pollution, causing increased risk for psychiatric outcomes. Effects of prenatal exposure to air pollution on early emerging behavioral phenotypes that increase risk of psychopathology remain understudied. We review animal models that represent analogues of human behavioral phenotypes that are risk markers for internalizing and externalizing problems (behavioral inhibition, behavioral exuberance, irritability), and identify commonalities among the neural mechanisms underlying these behavioral phenotypes and the neural targets of three types of air pollutants (polycyclic aromatic hydrocarbons, traffic-related air pollutants, fine particulate matter < 2.5 µm). We conclude that prenatal exposure to air pollutants increases risk for behavioral inhibition and irritability through distinct mechanisms, including altered dopaminergic signaling and hippocampal morphology, neuroinflammation, and decreased brain-derived neurotrophic factor expression. Future studies should investigate these effects in human longitudinal studies incorporating complex exposure measurement methods, neuroimaging, and behavioral characterization of temperament phenotypes and neurocognitive processing to facilitate efforts aimed at improving long-lasting developmental benefits for children, particularly those living in areas with high levels of exposure.pt_PT
dc.description.sponsorshipThis work was supported by the National Institutes of Environmental Health Sciences R01ES030950, R01ES032296 and K23026239 to A.E.M. and Whole Communities Whole Health, a University of Texas at Austin Grand Challenge Initiative (OVPR) to F.A.C.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeurosci Biobehav Rev. 2022 Jun;137:104645pt_PT
dc.identifier.doi10.1016/j.neubiorev.2022.104645pt_PT
dc.identifier.eissn1873-7528
dc.identifier.issn0149-7634
dc.identifier.urihttp://hdl.handle.net/10451/53326
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/neuroscience-and-biobehavioral-reviewspt_PT
dc.subjectAir pollutionpt_PT
dc.subjectAnimal modelspt_PT
dc.subjectBehavioral phenotypespt_PT
dc.subjectNeural mechanismspt_PT
dc.titleConvergent neural correlates of prenatal exposure to air pollution and behavioral phenotypes of risk for internalizing and externalizing problems: potential biological and cognitive pathwayspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleNeuroscience & Biobehavioral Reviewspt_PT
oaire.citation.volume137pt_PT
person.familyNameA. Conceição
person.givenNameVasco
person.identifier.ciencia-id8616-5268-7583
person.identifier.orcid0000-0003-2281-5748
person.identifier.ridF-4325-2018
person.identifier.scopus-author-id57195033520
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb0bbba17-65a5-4833-ad6c-263f8f876d88
relation.isAuthorOfPublication.latestForDiscoveryb0bbba17-65a5-4833-ad6c-263f8f876d88

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